Fe65 Antibody (D-11): sc-374641
- Fe65 Antibody (D-11) is a mouse monoclonal IgG3 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 63-101 near the N-terminus of Fe65 of human origin
- recommended for detection of Fe65 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fe65 Antibody (D-11). This work is in progress.
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Fe65 (D-11) is a mouse monoclonal IgG3 antibody. γ-secretase cleaves the cell surface protein amyloid protein precursor (APP) at the transmembrane region into an extracellular peptide (β-Amyloid) and an intracellular tail fragment. The cytoplasmic tail of APP forms a multimeric complex with Fe65 (also known as APBB1 for APP binding protein family B member 1). Specifically, Fe65 binds the YENPTY sequence in the cytoplasmic tail of APP. Fe65 is a nuclear adaptor protein widely expressed in the brain, including hippocampus and isocortex. In the cell, Fe65 and APP colocalize to the ER and Golgi. The interaction between APP and Fe65 increases the translocation of APP to the cell surface and the subsequent secretion of β-Amyloid. Fe65 and APP localize with Mena, a cell-adhesion protein, and Fe65 regulates APP-dependent changes in cell motility. The gene encoding human Fe65 maps to chromosome 11p15.
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Fe65 Antibody (D-11) References:
- The FE65 proteins and Alzheimer's disease. | McLoughlin, DM. and Miller, CC. 2008. J Neurosci Res. 86: 744-54. PMID: 17828772
- FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. | Cheung, HN., et al. 2014. FASEB J. 28: 337-49. PMID: 24056087
- Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage. | Langlands, H., et al. 2016. PLoS One. 11: e0155056. PMID: 27176072
- Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction. | Feilen, LP., et al. 2017. Front Mol Neurosci. 10: 140. PMID: 28553201
- Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. | Li, W., et al. 2018. J Biol Chem. 293: 7674-7688. PMID: 29615491
- FE65 in breast cancer and its clinicopathological significance. | Xu, J., et al. 2022. Breast Cancer. 29: 144-155. PMID: 34498219
- FE65 defines the efficacy of tamoxifen treatment via osteopontin expression in estrogen receptor-positive breast cancer. | Xu, J., et al. 2022. Pathol Res Pract. 234: 153898. PMID: 35447603
- ARNO is recruited by the neuronal adaptor FE65 to potentiate ARF6-mediated neurite outgrowth. | Zhai, Y., et al. 2022. Open Biol. 12: 220071. PMID: 36168805
- Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease. | Iyaswamy, A., et al. 2023. Signal Transduct Target Ther. 8: 404. PMID: 37867176
- Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair. | Revol, RS., et al. 2023. Mol Cell Neurosci. 127: 103903. PMID: 37918552
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fe65 Antibody (D-11) | sc-374641 | 200 µg/ml | $322.00 | |||
Fe65 Antibody (D-11): m-IgGκ BP-HRP Bundle | sc-551780 | 200 µg Ab; 40 µg BP | $361.00 | |||
Fe65 (D-11) Neutralizing Peptide | sc-374641 P | 100 µg/0.5 ml | $69.00 |