Date published: 2026-10-24

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Ezrin 抗体 (E-8): sc-398807

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说明书
  • Ezrin抗体(E-8)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的Ezrin的C-terminus的氨基酸559-584之间
  • 推荐用于 mouse, rat 和 human 来源的Ezrin, Ermin, Radixin and Moesin WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 Ezrin (H-4): sc-398542,可查看有标记的 Ezrin 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Ezrin Antibody (E-8) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Ezrin Antibody (E-8) 打包提供(请参阅下面的订购信息)。
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    関連項目

    Ezrin、Moesin和Radixin属于高同源肌动蛋白相关蛋白家族,仅位于质膜之下。这些蛋白质被认为参与介导细胞骨架和膜蛋白之间的相互作用。Ezrin是各种蛋白酪氨酸激酶的主要细胞质底物,包括表皮生长因子受体。Ezrin也被鉴定为cAMP依赖性蛋白激酶(A激酶)锚定蛋白,并被命名为AKAP78。Moesin和Radixin与Ezrin具有70%以上的同源性,并在各种细胞类型中共同表达。尽管同源性很高,但这三种蛋白质表现出独特的受体特异性磷酸化模式。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Ezrin 抗体 (E-8) 参考文献:

    1. Ezrin免疫反应揭示了脑部HIV中星形胶质细胞的特异性激活。  |  Geiger, KD., et al. 2006. J Neuropathol Exp Neurol. 65: 87-96. PMID: 16410752
    2. Ezrin是死亡受体诱导细胞凋亡的负调控因子  |  Kuo, WC., et al. 2010. Oncogene. 29: 1374-83. PMID: 19935704
    3. Ezrin 酪氨酸 477 上的磷酸化调节乳腺癌细胞的侵袭和转移。  |  Mak, H., et al. 2012. BMC Cancer. 12: 82. PMID: 22397367
    4. PI(4,5)P₂聚集和ezrin磷酸化响应CLIC5A。  |  Al-Momany, A., et al. 2014. J Cell Sci. 127: 5164-78. PMID: 25344252
    5. Ezrin自身抗体与胰腺癌风险的前瞻性研究。  |  Sun, Y., et al. 2016. Cancer Causes Control. 27: 831-5. PMID: 27146838
    6. Ezrin表达与MSI状态相结合,用于II期结直肠癌的预后。  |  Slik, K., et al. 2017. PLoS One. 12: e0185436. PMID: 28953975
    7. 敲除Ezrin抑制宫颈癌细胞在体外迁移和侵袭。  |  Xi, M. and Tang, W. 2020. Int J Immunopathol Pharmacol. 34: 2058738420930899. PMID: 32674647
    8. 淋球菌对上皮细胞的侵袭取决于细胞极性和 ezrin。  |  Yu, Q., et al. 2021. PLoS Pathog. 17: e1009592. PMID: 34852011
    9. 乳腺癌中 ezrin 蛋白和 mRNA 表达的回顾性分析:Ezrin 表达与患者生存和受体阳性疾病患者的生存相关。  |  Storr, SJ., et al. 2023. Cancer Med. 12: 10908-10916. PMID: 36938826
    10. Ezrin与糖尿病相关的呼吸道上皮屏障损伤有关。  |  Yu, H., et al. 2024. J Inflamm Res. 17: 2609-2621. PMID: 38689797

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Ezrin 抗体 (E-8)

    sc-398807
    200 µg/ml
    $322.00

    Ezrin (E-8): m-IgG Fc BP-HRP 套装

    sc-538525
    200 µg Ab; 10 µg BP
    $361.00

    Ezrin (E-8): m-IgGκ BP-HRP 套装

    sc-536153
    200 µg Ab; 40 µg BP
    $361.00

    Ezrin (E-8): m-IgG1 BP-HRP 套装

    sc-545750
    200 µg Ab; 20 µg BP
    $361.00

    Ezrin (E-8) 中和勝肽

    sc-398807 P
    100 µg/0.5 ml
    $69.00

    What application is the blocking peptide sc-398807 P appropriate for?

    Asked by: Trav11
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-24
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    Rated 5 out of 5 by HC from Strong positive band detected in WB in AStrong positive band detected in WB in A-431, Ramos, MCF7, HT-29 and K-562 whole cell lysates. -SCBT QC
    Date published: 2015-05-27
    Rated 5 out of 5 by FL from Very robust band of interest observed inVery robust band of interest observed in WB in human Ezrin transfected whole cell lysate. -SCBT QC
    Date published: 2015-04-03
    Rated 5 out of 5 by MS from Produced great immunofluorescence cytoskeletalProduced great immunofluorescence cytoskeletal staining in methanol-fixed HeLa cells. -SCBT QC
    Date published: 2015-03-31
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    Ezrin 抗体 (E-8) is rated 5.0 out of 5 by 3.
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