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Ezrin 抗体 (C-4): sc-271541

5.0(3)
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说明书
  • Ezrin抗体(C-4)是小鼠单克隆IgG1 κ, 在1篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列1-300位于human物种的Ezrin的N-terminus
  • 推荐用于 mouse, rat 和 human 来源的Ezrin, Radixin and Moesin WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 Ezrin (H-4): sc-398542,可查看有标记的 Ezrin 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Ezrin Antibody (C-4) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Ezrin Antibody (C-4) 打包提供(请参阅下面的订购信息)。
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Ezrin、Moesin和Radixin属于高同源肌动蛋白相关蛋白家族,仅位于质膜之下。这些蛋白质被认为参与介导细胞骨架和膜蛋白之间的相互作用。Ezrin是各种蛋白酪氨酸激酶的主要细胞质底物,包括表皮生长因子受体。Ezrin也被鉴定为cAMP依赖性蛋白激酶(A激酶)锚定蛋白,并被命名为AKAP78。Moesin和Radixin与Ezrin具有70%以上的同源性,并在各种细胞类型中共同表达。尽管同源性很高,但这三种蛋白质表现出独特的受体特异性磷酸化模式。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Ezrin 抗体 (C-4) 参考文献:

  1. Ezrin调节体液免疫的强度。  |  Pore, D., et al. 2013. J Immunol. 191: 4048-58. PMID: 24043890
  2. 非小细胞肺癌中 ezrin 和磷酸化 ezrin 表达的预后意义  |  Jin, T., et al. 2014. BMC Cancer. 14: 191. PMID: 24629131
  3. Ezrin促进MG63骨肉瘤细胞的侵袭和迁移。  |  Zhang, J., et al. 2014. Chin Med J (Engl). 127: 1954-9. PMID: 24824262
  4. A549细胞中TGF-β1诱导的上皮-间质转化需要Ezrin。  |  Chen, MJ., et al. 2014. Int J Oncol. 45: 1515-22. PMID: 25051016
  5. Ezrin Thr567磷酸化决定了人阻塞性胆汁淤积中管壁MRP2/ABCC2的内化。  |  Chai, J., et al. 2015. J Hepatol. 63: 1440-8. PMID: 26212029
  6. Ezrin在Luminal A、Luminal B和HER2亚型乳腺癌中显著过度表达。  |  Jais, MH., et al. 2017. Appl Immunohistochem Mol Morphol. 25: 44-48. PMID: 26469327
  7. Ezrin-膜相互作用模式作为PIP2结合和假磷酸化的一种功能。  |  Shabardina, V., et al. 2016. Biophys J. 110: 2710-2719. PMID: 27332129
  8. Ezrin与卵巢癌的疾病进展有关  |  Horwitz, V., et al. 2016. PLoS One. 11: e0162502. PMID: 27622508
  9. Ezrin 与肿瘤抑制因子 CHL1 相互作用,促进人类神经母细胞瘤的神经元分化。  |  Ognibene, M. and Pezzolo, A. 2020. PLoS One. 15: e0244069. PMID: 33326488
  10. NSC305787是一种药理ezrin抑制剂,在胰腺癌细胞中表现出抗肿瘤活性。  |  Lipreri da Silva, JC., et al. 2022. Invest New Drugs. 40: 728-737. PMID: 35477813

订购信息

产品名称产品编号规格价格数量收藏夹

Ezrin 抗体 (C-4)

sc-271541
200 µg/ml
$322.00

Ezrin (C-4): m-IgG Fc BP-HRP 套装

sc-537659
200 µg Ab; 10 µg BP
$361.00

Ezrin (C-4): m-IgGκ BP-HRP 套装

sc-534993
200 µg Ab; 40 µg BP
$361.00

Ezrin (C-4): m-IgG1 BP-HRP 套装

sc-545288
200 µg Ab; 20 µg BP
$361.00

Una volta Santa Cruz vendeva un anticorpo policlonale di coniglio anti ezrina. Non lo trovo più in catalogo.

Asked by: AEva
Grazie per la sua domanda. L´anticorpo policlonale Ezrin (H-276): sc-20773 non é piú disponible. Tuttavia abbiamo una vasta scelta di anticorpi monoclonali specifici contro la proteina Ezrin nel nostro catalogo che puó osservare al seguente link: https://www.scbt.com/scbt/browse/ezrin-Antibodies/_/N-18n2irp Tra le varie alternative le consigliamo di acquistare il popolare Anticorpo Ezrin sc-58758 Ezrin (3C12) raccomandato per il rilevamento di Ezrin di origine topo, ratto, umana e bovina in WB, IP, IF e IHC(P) Contatti il nostro servizio tecnico per ricevere ulteriori informazioni. Thank you for your question. The polyclonal Ezrin Antibody (H-276): sc-20773 has been discontinued in 2016. However there is a variety of monoclonal antibodies specific against Ezrin in our portfolio. An overview of these products can be found by following this link: https://www.scbt.com/scbt/browse/ezrin-Antibodies/_/N-18n2irp Ezrin Antibody (3C12): sc-58758 is particularly popular and may be a suitable alternative. It is recommended for detection of Ezrin of mouse, rat, human and bovine origin by WB, IP, IF and IHC(P)
Answered by: Technical Support Europe
Date published: 2019-01-15

What is the difference between Ezrin C-4 (product#sc-271541) and A-4 (product#sc-271456)

Asked by: experiem
Thank you for your question. These two antibodies are very similar. Both are mouse monoclonal antibodies raised against the same recombinant protein immunogen. The only difference is that each clone, (C-4) and (A-4), has a unique epitope. Both antibodies have excellent data in WB, IF and IHC(P).
Answered by: Technical Support
Date published: 2017-08-03

Can Ezrin (C-4): sc-271541 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Trav11
Thank you for your question. Yes, Ezrin (C-4): sc-271541 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by TS from Robust band detected in WB in human EzrinRobust band detected in WB in human Ezrin transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-05-13
Rated 5 out of 5 by JM from Produced beautiful immunoperoxidase cytoplasmicProduced beautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human urinary bladder tissue. -SCBT QC
Date published: 2015-05-05
Rated 5 out of 5 by JM from Strong band of interest detected in WB inStrong band of interest detected in WB in HeLa and Ramos whole cell lysates. -SCBT QC
Date published: 2015-02-10
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Ezrin 抗体 (C-4) is rated 5.0 out of 5 by 3.
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