ERp46 Antibody (F-3): sc-271465
- ERp46 Antibody (F-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 137-216 mapping within an internal region of ERp46 of human origin
- recommended for detection of ERp46 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ERp46 Antibody (F-3) for WB and IHC(P) applications. These reagents are now offered in bundles with ERp46 Antibody (F-3) (see ordering information below).
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ERp46 Antibody (F-3) is a mouse monoclonal IgG1 antibody that detects ERp46 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ERp46, also known as thioredoxin domain containing 5 (TXNDC5), is a crucial member of the thioredoxin superfamily, characterized by its thioredoxin fold and a consensus active-site sequence (CxxC). ERp46 is predominantly localized in the endoplasmic reticulum (ER), where anti-ERp46 antibody (F-3) helps researchers study protein folding and quality control processes, ensuring that only properly folded proteins are transported to their final destinations. ERp46′s function is highlighted by its ability to reduce insulin disulfide bonds, which is essential for maintaining the structural integrity of insulin and other secretory proteins. ERp46 has been shown to complement protein disulfide-isomerase deficiency in yeast, highlighting its functional versatility. ERp46 expression is induced under hypoxic conditions, suggesting a protective role against apoptosis in hypoxic cells, thereby contributing to cellular survival in adverse environments. ERp46 (F-3) antibody is an invaluable tool for researchers studying the intricate mechanisms of protein folding and the cellular responses to stress.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ERp46 Antibody (F-3) References:
- ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins. | Knoblach, B., et al. 2003. Mol Cell Proteomics. 2: 1104-19. PMID: 12930873
- ERp46 is reduced by high glucose and regulates insulin content in pancreatic beta-cells. | Alberti, A., et al. 2009. Am J Physiol Endocrinol Metab. 297: E812-21. PMID: 19622788
- ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling. | Charlton, HK., et al. 2010. Biochem Biophys Res Commun. 392: 234-9. PMID: 20074551
- Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46. | Funkner, A., et al. 2013. J Mol Biol. 425: 1340-62. PMID: 23376096
- Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46. | Pace, PE., et al. 2013. Biochem J. 453: 475-85. PMID: 23713588
- Endoplasmic reticulum protein ERp46 in renal cell carcinoma. | Duivenvoorden, WC., et al. 2014. PLoS One. 9: e90389. PMID: 24594673
- Reduced expression of ERp46 under diabetic conditions in β-cells and the effect of liraglutide. | Lampropoulou, E., et al. 2016. Metabolism. 65: 7-15. PMID: 26683792
- Endoplasmic reticulum protein ERp46 in prostate adenocarcinoma. | Duivenvoorden, WCM., et al. 2017. Oncol Lett. 13: 3624-3630. PMID: 28521463
- ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation-enhancing α-mannosidase-like protein 3 (EDEM3). | Yu, S., et al. 2018. J Biol Chem. 293: 10663-10674. PMID: 29784879
- A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. | Zhou, J., et al. 2022. Blood. 139: 2050-2065. PMID: 34752599
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERp46 Antibody (F-3) | sc-271465 | 200 µg/ml | $322.00 | |||
ERp46 Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-537641 | 200 µg Ab; 10 µg BP | $361.00 | |||
ERp46 Antibody (F-3): m-IgGκ BP-HRP Bundle | sc-534972 | 200 µg Ab; 40 µg BP | $361.00 | |||
ERp46 Antibody (F-3): m-IgG1 BP-HRP Bundle | sc-545277 | 200 µg Ab; 20 µg BP | $361.00 |