EGFR Antibody (F-9): sc-377073

EGFR Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects amino acids 1131-1169 within a C-terminal cytoplasmic domain of EGFR in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). EGFR, or epidermal growth factor receptor, is frequently overexpressed or mutated in tumor tissues, where EGFR contributes to cancer progression by driving aberrant cell proliferation and survival. EGFR expression in tumor tissues is often associated with aggressive phenotypes, including increased invasive potential and resistance to therapies. EGFR is primarily located on the cell membrane, where EGFR binds ligands such as epidermal growth factor and transforming growth factor alpha, triggering receptor dimerization and activation. This activation leads to the stimulation of downstream signaling pathways, including RAS-RAF-MAPK and PI3K-AKT, which are co-opted by cancer cells to support uncontrolled growth and metastasis. The prevalence of EGFR in a variety of tumors has made EGFR a key biomarker and crucial target for therapeutic interventions in oncology. Anti-EGFR antibody (F-9) is an invaluable tool for researchers studying EGFR′s role in both normal physiology and pathological conditions, providing insights into potential therapeutic strategies for targeting this receptor in cancer treatment.

The preferred EGFR antibody is EGFR Antibody (528): sc-120.