EGFR Antibody (0.N.268): sc-71034

EGFR Antibody (0.N.268) is a mouse monoclonal IgG1 antibody that detects EGFR in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. EGFR, or epidermal growth factor receptor, is a critical receptor tyrosine kinase that plays a pivotal role in cell signaling pathways that regulate cell proliferation, survival, and differentiation. EGFR is frequently overexpressed in various carcinomas, leading to enhanced tumor growth and metastasis. EGFR′s ability to form homodimers and heterodimers upon ligand binding, such as with epidermal growth factor and transforming growth factor alpha, initiates a cascade of intracellular signaling that can result in oncogenic effects, including the initiation of DNA synthesis and increased cell invasion. The internalization and degradation of EGFR following ligand binding are crucial for regulating activity and preventing excessive signaling, which can contribute to tumor progression. Given its significant role in cancer biology, EGFR is considered a promising therapeutic target, and anti-EGFR antibody (0.N.268) provides a valuable tool for researchers investigating function and implications in various diseases.

The preferred EGFR antibody is EGFR Antibody (528): sc-120.