E4BP4 Antibody (F-1): sc-74414
- E4BP4 Antibody (F-1) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 163-462 mapping at the C-terminus of E4BP4 of human origin
- recommended for detection of E4BP4 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-74414 X, 200 µg/0.1 ml)
- m-IgG2a BP-HRP is the preferred secondary detection reagent for E4BP4 Antibody (F-1) for WB applications. This reagent is now offered in a bundle with E4BP4 Antibody (F-1) (see ordering information below).
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E4BP4 Antibody (F-1) is a mouse monoclonal IgG2a antibody that detects E4BP4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). E4BP4, also known as NFIL3, is a crucial transcriptional repressor belonging to the basic leucine zipper (bZIP) transcription factor family, which plays a significant role in regulating gene expression. E4BP4 is primarily located in the nucleus, where E4BP4 binds to specific DNA sequences, including the E4 ATF, to modulate the transcriptional activity of various genes. E4BP4′s ability to compete with PAR proteins for DNA binding is particularly important in the suprachiasmatic nucleus, the brain′s circadian center, and the liver, as E4BP4 helps maintain the balance of gene expression in accordance with the circadian rhythm. Additionally, E4BP4 is involved in the IL-3-mediated signaling pathway, which is essential for the survival of B cell progenitors, highlighting E4BP4′s importance in both circadian regulation and immune system function. The gene encoding human E4BP4 is located on chromosome 9q22, further emphasizing E4BP4′s relevance in human biology and disease.
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E4BP4 Antibody (F-1) References:
- The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases. | Yin, J., et al. 2017. Clin Immunol. 180: 5-10. PMID: 28365317
- E4BP4 mediates glucocorticoid-regulated adipogenesis through COX2. | Yang, Y., et al. 2017. Mol Cell Endocrinol. 450: 43-53. PMID: 28416324
- A minireview of E4BP4/NFIL3 in heart failure. | Velmurugan, BK., et al. 2018. J Cell Physiol. 233: 8458-8466. PMID: 29856483
- Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function. | Dierickx, P., et al. 2022. Nat Cardiovasc Res. 1: 45-58. PMID: 35036997
- E4BP4 Coordinates Circadian Control of Cognition in Delirium. | Chen, M., et al. 2022. Adv Sci (Weinh). 9: e2200559. PMID: 35713240
- High-Fat Diet-Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice. | Wang, S., et al. 2023. Diabetes. 72: 348-361. PMID: 36508222
- Circadian-Regulated Cardiac Metabolism Involves Transcription Factor E4BP4. | Rabinovich-Nikitin, I. and Kirshenbaum, LA. 2023. JACC Basic Transl Sci. 8: 1157-1159. PMID: 37791305
- Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology. | Mia, S., et al. 2023. JACC Basic Transl Sci. 8: 1141-1156. PMID: 37791313
- E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis. | Kajimura, Y., et al. 2024. Commun Biol. 7: 527. PMID: 38714733
- OPN-Mediated Crosstalk Between Hepatocyte E4BP4 and Hepatic Stellate Cells Promotes MASH-Associated Liver Fibrosis. | Wang, S., et al. 2024. Adv Sci (Weinh). 11: e2405678. PMID: 39473081
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E4BP4 Antibody (F-1) | sc-74414 | 200 µg/ml | $322.00 | |||
E4BP4 Antibody (F-1): m-IgG2a BP-HRP Bundle | sc-546008 | 200 µg Ab; 10 µg BP | $361.00 | |||
E4BP4 Antibody (F-1) X | sc-74414 X | 200 µg/0.1 ml | $322.00 |