Dyskerin Antibody (C-11): sc-365731
- Dyskerin Antibody (C-11) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 171-470 mapping within an internal region of Dyskerin of human origin
- recommended for detection of Dyskerin of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-365731 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Dyskerin Antibody (C-11) for WB applications. These reagents are now offered in bundles with Dyskerin Antibody (C-11) (see ordering information below).
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SEE ALSO...
Dyskerin Antibody (C-11) is a mouse monoclonal IgG1 antibody that detects dyskerin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dyskerin plays a crucial role in the biogenesis of ribonucleoprotein complexes, particularly in the modification of uridine to pseudouridine, which is essential for the proper functioning of ribosomal RNA and, consequently, protein synthesis. This modification enhances the stability and functionality of RNA molecules, impacting cellular processes such as translation and ribosome assembly. Dyskerin forms a small ribonucleoprotein particle with other proteins, including Nopp140, GAR1, NHP2, and Nop10, which localize to the dense fibrillar component of the nucleolus and nuclear Cajal bodies, highlighting dyskerin′s importance in nucleolar function and cellular homeostasis. Dyskerin is encoded by a gene located on chromosome Xq28, and mutations in this gene can disrupt normal localization, leading to Dyskeratosis congenita, a rare X-linked disorder characterized by various clinical manifestations, including skin pigmentation abnormalities and bone marrow failure. Anti-dyskerin antibody (C-11) is an invaluable tool for researchers studying ribonucleoprotein complexes and their implications in cellular biology and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dyskerin Antibody (C-11) | sc-365731 | 200 µg/ml | $322.00 | |||
Dyskerin Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-540362 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dyskerin Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-542069 | 200 µg Ab; 20 µg BP | $361.00 | |||
Dyskerin Antibody (C-11) X | sc-365731 X | 200 µg/0.1 ml | $322.00 |