DNA pol δ cat Antibody (F-9): sc-373731

DNA pol δ cat Antibody (F-9) is a mouse monoclonal IgG2b antibody that detects DNA polymerase delta (DNA pol δ) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DNA pol δ is a crucial enzyme involved in DNA replication, recombination, and repair, all of which are essential for maintaining genome stability. Anti-DNA pol δ antibody (F-9) helps researchers study processes like Okazaki fragment processing during DNA replication and damaged DNA excision during repair, which prevent mutations leading to genomic instability and diseases such as cancer. DNA pol δ is composed of two subunits, p125 and p50, with p125 directly interacting with the sliding DNA clamp protein PCNA, which is vital for the enzyme′s function and efficiency. DNA pol δ activity is regulated by various cell cycle proteins, ensuring tight control during different cell cycle phases. Understanding DNA pol δ dynamics and interactions is critical for elucidating DNA replication and repair mechanisms, making DNA pol δ cat (F-9) monoclonal antibody an invaluable research tool for studying these fundamental biological processes.

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DNA pol δ cat Antibody (F-9) References:

1. Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers.  |  Jansen, AM., et al. 2016. Eur J Hum Genet. 24: 1089-92. PMID: 26648449
2. A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers.  |  Hocke, S., et al. 2016. Oncotarget. 7: 7080-95. PMID: 26755646
3. Comprehensive analysis of POLE and POLD1 Gene Variations identifies cancer patients potentially benefit from immunotherapy in Chinese population.  |  Yao, J., et al. 2019. Sci Rep. 9: 15767. PMID: 31673068
4. Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region.  |  Siraj, AK., et al. 2019. Cancer Cell Int. 19: 334. PMID: 31866764
5. POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features.  |  Oh, DY., et al. 2020. Hum Mutat. 41: 913-920. PMID: 31944473
6. Pedigree analysis of a POLD1 germline mutation in urothelial carcinoma shows a close association between different mutation burdens and overall survival.  |  Wang, Y., et al. 2021. Cell Mol Immunol. 18: 767-769. PMID: 32265515
7. A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation.  |  Chen, T., et al. 2022. Biol Open. 11: PMID: 35876795
8. POLD1 Is Required for Cell Cycle Progression by Overcoming DNA Damage in Malignant Pleural Mesothelioma.  |  Shimizu, D., et al. 2024. Cancer Genomics Proteomics. 21: 158-165. PMID: 38423601
9. A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/POLD1) mutation.  |  Jin, Y., et al. 2024. Signal Transduct Target Ther. 9: 227. PMID: 39218995
10. Helicobacter pylori infection induces DNA double-strand breaks through the ACVR1/IRF3/POLD1 signaling axis to drive gastric tumorigenesis.  |  Xu, X., et al. 2025. Gut Microbes. 17: 2463581. PMID: 39924917

The preferred DNA pol δ cat antibody is DNA pol δ cat Antibody (A-9): sc-17776.