Date published: 2025-9-6

021-6093-6350

SCBT Portrait Logo
Seach Input

Cripto 抗体 (H-10): sc-376448

3.4(5)
寫評論提問

说明书
  • Cripto 抗体 H-10 是小鼠单克隆 IgG1 κ,Cripto抗体, 在4篇文献中引用,规格为200 µg/ml
  • 免疫human物种的代表全长Cripto的氨基酸1-188
  • Cripto 抗体 (H-10) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 Cripto
  • 抗Cripto抗体(H-10)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Cripto (H-10): sc-376448免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 Cripto 抗体 (H-10) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Cripto 抗体 (H-10) 组合成套装提供。 (请参阅下面的订购信息)。

快捷链接

関連項目

Cripto抗体(H-10)是一种IgG1 κ小鼠单克隆Cripto抗体(也被称为Cripto抗体),可通过WB、IP、IF、IHC(P)和ELISA方法检测人源Cripto蛋白。Cripto抗体(H-10)既有非偶联形式的抗Cripto抗体,也有多种偶联形式的抗Cripto抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。畸胎癌衍生生长因子(TDGF)-1基因编码一种名为cripto-1(Cripto)的蛋白质。Cripto首先在原肠胚形成过程中的形成中胚层中表达,但在随后的发育过程中,其表达仅限于发育中心脏的动脉干。这表明Cripto介导了产生中胚层的外胚层细胞的进展。在成年动物中,它在脾脏、心脏、肺和大脑中的表达水平较低。Cripto的过度表达是人类胃癌和结直肠癌的特征。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cripto 抗体 (H-10) 参考文献:

  1. 在人类结肠癌细胞系和肿瘤中表达的截短形式的畸胎瘤衍生生长因子-1(cripto-1)mRNA。  |  Baldassarre, G., et al. 2001. Tumour Biol. 22: 286-93. PMID: 11553858
  2. Cripto:肿瘤生长因子等。  |  Adamson, ED., et al. 2002. J Cell Physiol. 190: 267-78. PMID: 11857442
  3. Cripto 与活化素和 II 型活化素受体形成复合物,可以阻断活化素信号传导。  |  Gray, PC., et al. 2003. Proc Natl Acad Sci U S A. 100: 5193-8. PMID: 12682303
  4. 解密 Cripto 在肿瘤发生中的作用。  |  Shen, MM. 2003. J Clin Invest. 112: 500-2. PMID: 12925690
  5. 依赖结节的Cripto信号促进心肌生成,并重定向胚胎干细胞的神经命运。  |  Parisi, S., et al. 2003. J Cell Biol. 163: 303-14. PMID: 14581455
  6. Cripto:基于抗体的癌症免疫疗法的新靶点。  |  Xing, PX., et al. 2004. Cancer Res. 64: 4018-23. PMID: 15173016
  7. 人类 Cripto-1 作为癌症疫苗的靶标:WO2008040759。  |  Bianco, C. and Salomon, DS. 2009. Expert Opin Ther Pat. 19: 141-4. PMID: 19441915
  8. Cripto-1:一种促进肿瘤发生的胚胎基因。  |  de Castro, NP., et al. 2010. Future Oncol. 6: 1127-42. PMID: 20624125
  9. 靶向 Nodal 和 Cripto-1:双重潜在治疗癌症生物标记物的内部视角。  |  Sandomenico, A. and Ruvo, M. 2019. Curr Med Chem. 26: 1994-2050. PMID: 30207211
  10. Cripto-1是肿瘤进展、上皮细胞向间质转化和癌症干细胞的关键因素。  |  Arnouk, H., et al. 2021. Int J Mol Sci. 22: PMID: 34502188
  11. 小鼠 cripto 基因:在中胚层诱导和早期心脏形态发生过程中的表达。  |  Dono, R., et al. 1993. Development. 118: 1157-68. PMID: 7916676
  12. 表皮生长因子相关蛋白:Cripto-1 的鉴定和生物学特性。  |  Brandt, R., et al. 1994. J Biol Chem. 269: 17320-8. PMID: 8006041

订购信息

产品名称产品编号规格价格数量收藏夹

Cripto 抗体 (H-10)

sc-376448
200 µg/ml
$316.00

Cripto (H-10): m-IgG Fc BP-HRP 套装

sc-551724
200 µg Ab; 10 µg BP
$354.00

Cripto (H-10): m-IgG1 BP-HRP 套装

sc-551725
200 µg Ab; 20 µg BP
$354.00

Cripto 抗体 (H-10) AC

sc-376448 AC
500 µg/ml, 25% agarose
$416.00

Cripto 抗体 (H-10) HRP

sc-376448 HRP
200 µg/ml
$316.00

Cripto 抗体 (H-10) FITC

sc-376448 FITC
200 µg/ml
$330.00

Cripto 抗体 (H-10) PE

sc-376448 PE
200 µg/ml
$343.00

Cripto 抗体 (H-10) Alexa Fluor® 488

sc-376448 AF488
200 µg/ml
$357.00

Cripto 抗体 (H-10) Alexa Fluor® 546

sc-376448 AF546
200 µg/ml
$357.00

Cripto 抗体 (H-10) Alexa Fluor® 594

sc-376448 AF594
200 µg/ml
$357.00

Cripto 抗体 (H-10) Alexa Fluor® 647

sc-376448 AF647
200 µg/ml
$357.00

Cripto 抗体 (H-10) Alexa Fluor® 680

sc-376448 AF680
200 µg/ml
$357.00

Cripto 抗体 (H-10) Alexa Fluor® 790

sc-376448 AF790
200 µg/ml
$357.00

Can Cripto (H-10): sc-376448 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Germaine
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Cripto (H-10): sc-376448 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_8, d_29, h_8CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_376448, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 113ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Great results using Santa Cruz Cr-1 antibody.We have been investigating the expression of Cripto-1 in reproductive tissues and particularly in trophoblast cells. Our results showed gene and protein up-regulation of this factor in placentation associated with abnormal trophoblast invasion (creta placentas, Bandeira et al: BioMed Research International, 2014). Cr-1 silencing decreased the invasive capacity of the trophoblast cell lineages and suppressed specific signaling pathways, also found in cancer cells. The putative role of this factor in determining diagnosis and prognosis of conditions associated with abnormal invasion of the trophoblast is, therefore, promissory.
Date published: 2017-05-25
Rated 1 out of 5 by from non specific bandsin the low dilution I did not get the band and when I increase the dilution many nonspecific band showed up in the membrane
Date published: 2016-11-29
Rated 1 out of 5 by from Not what I expect!used with PC3MM cell line in western blot, no band in the 1:500 dilution but a lot of unspecific bands in 1:125 dilution.
Date published: 2016-11-19
Rated 5 out of 5 by from Exceptional immunoperoxidase cytoplasmicExceptional immunoperoxidase cytoplasmic and membrane staining in formalin fixed, paraffin-embedded human testis tissue. -SCBT QC
Date published: 2015-01-13
  • y_2025, m_8, d_29, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_1, tr_4
  • loc_zh_CN, sid_376448, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 17ms
  • REVIEWS, PRODUCT
Cripto 抗体 (H-10) is rated 3.4 out of 5 by 5.
  • y_2025, m_8, d_29, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_1, tr_4
  • loc_zh_CN, sid_376448, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 126ms
  • REVIEWS, PRODUCT