COG7 Antibody (L-06): sc-101279
- COG7 Antibody (L-06) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against recombinant COG7 of human origin
- recommended for detection of COG7 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for COG7 Antibody (L-06). This work is in progress.
QUICK LINKS
COG7 Antibody (L-06) is a mouse monoclonal IgG1 antibody that detects COG7 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COG7, also known as CDG2E, is a 770 amino acid peripheral membrane protein that plays a crucial role in the structure and function of the Golgi apparatus, which is essential for proper glycosylation and vesicular transport processes. COG7 is a vital component of the conserved oligomeric Golgi (COG) complex, which consists of three subcomplexes—LDLC, SEC34, and GTT—that work together to maintain Golgi integrity and facilitate vesicle docking and fusion. The importance of COG7 is underscored by its involvement in congenital disorders of glycosylation type 2E (CDG2E), where mutations in the COG7 gene lead to significant clinical manifestations, including psychomotor retardation, hypotonia, coagulation disorders, and immunodeficiency due to impaired N-glycosylation. Anti-COG7 antibody (L-06) enables researchers to gain insights into the functional dynamics of the Golgi apparatus and the pathological mechanisms underlying glycosylation disorders, making this tool invaluable for both basic and clinical research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COG7 Antibody (L-06) References:
- The binary interacting network of the conserved oligomeric Golgi tethering complex. | Loh, E. and Hong, W. 2004. J Biol Chem. 279: 24640-8. PMID: 15047703
- Molecular and clinical characterization of a Moroccan Cog7 deficient patient. | Ng, BG., et al. 2007. Mol Genet Metab. 91: 201-4. PMID: 17395513
- Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. | Smith, RD. and Lupashin, VV. 2008. Carbohydr Res. 343: 2024-31. PMID: 18353293
- A new mutation in COG7 extends the spectrum of COG subunit deficiencies. | Zeevaert, R., et al. 2009. Eur J Med Genet. 52: 303-5. PMID: 19577670
- Metabolic cutis laxa syndromes. | Mohamed, M., et al. 2011. J Inherit Metab Dis. 34: 907-16. PMID: 21431621
- Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis. | Belloni, G., et al. 2012. J Cell Sci. 125: 5441-52. PMID: 22946051
- Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. | Ha, JY., et al. 2014. Proc Natl Acad Sci U S A. 111: 15762-7. PMID: 25331899
- COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes. | Frappaolo, A., et al. 2017. J Cell Sci. 130: 3637-3649. PMID: 28883096
- Metabolic Cardiomyopathies and Cardiac Defects in Inherited Disorders of Carbohydrate Metabolism: A Systematic Review. | Conte, F., et al. 2023. Int J Mol Sci. 24: PMID: 37239976
- COG-imposed Golgi functional integrity determines the onset of dark-induced senescence. | Choi, HS., et al. 2023. Nat Plants. 9: 1890-1901. PMID: 37884654
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COG7 Antibody (L-06) | sc-101279 | 100 µg/ml | $339.00 |