m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred secondary detection reagent for cGKIα/β Antibody (G-3) for WB applications. This reagent is now offered in a bundle with cGKIα/β Antibody (G-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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cGKI (cGMP-dependent protein kinase type I), also known as PRKG1, lowers the intracellular level of calcium and is important for the relaxation of vascular smooth muscle. cGKI exists as two alternatively spliced isoforms, designated α and β, which differ only in their N-terminal sequence and function to catalyze the phosphorylation of target proteins. The cGKIα/β precursor contains one protein kinase domain, one AGC-kinase C-terminal domain and two cyclic nucleotide-binding domains. cGKII (cGMP-dependent protein kinase type II), a protein that is related to cGKI, is a major receptor of intracellular cGMP that mediates a plethora of physiological responses. cGKII contains a conserved leucine zipper motif at the amino terminus and is expressed in small intestine, colon, prostate and human brain tissue. cGKII has been shown to regulate the ion transport system in the intestine. Myristoylation of the penultimate glycine in cGKII appears to be essential for directing cGKII to the membrane, since cGKII is devoid of any hydrophobic transmembrane domains.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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