Date published: 2025-9-6
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CEACAM5 Antibody (CI-P83-1) - Western Blotting - Image 9074
CEACAM5 抗体 (CI-P83-1): sc-23928. T84 全细胞裂解液中 CEACAM5 表达的 Western 印迹分析.
CEACAM5 抗体 (CI-P83-1): sc-23928. T84 全细胞裂解液中 CEACAM5 表达的 Western 印迹分析.

CEACAM5 抗体 (CI-P83-1): sc-23928

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说明书
  • CEACAM5 抗体 CI-P83-1 是小鼠单克隆 IgG1 κ，CEACAM5抗体, 在10篇文献中引用，规格为200 µg/ml
  • 免疫human物种的CEA-180
  • CEACAM5 抗体 (CI-P83-1) 推荐用于 WB, IP, IF, IHC(P) 和 FCM，检测mouse, rat 和human 来源的 CEACAM5; 不会与 CD66c, CD66a or granulocytes产生交联反应
  • 抗CEACAM5抗体（CI-P83-1）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CEACAM5 (CI-P83-1): sc-23928的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP 是 CEACAM5 抗体 (CI-P83-1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与CEACAM5 抗体 (CI-P83-1) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGκ BP 偶联产品，请参阅我们的小鼠 IgG 结合蛋白完整列表。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 CEACAM 抗体 包括 CEACAM1, CEACAM16, CEACAM19, CEACAM2, CEACAM20, CEACAM3, CEACAM5, CEACAM6和CEACAM7

CEACAM5抗体（CI-P83-1）是一种鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和流式细胞术（FCM）检测小鼠、大鼠和人类来源的CEACAM5蛋白。抗CEACAM5抗体（CI-P83-1）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。CEACAM5，也称为CD66e，是一种高度糖基化的糖磷脂酰肌醇（GPI）锚定蛋白，在细胞粘附和信号传导中发挥着关键作用，尤其是在肿瘤生物学中。CEACAM5在多种癌症中的表达显著上调，因此CEACAM5成为诊断和治疗应用中极具价值的肿瘤标志物。CEACAM5主要位于上皮细胞表面，促进细胞间粘附和沟通，对于维持组织完整性和调节免疫反应至关重要。肿瘤细胞上的CEACAM5可促进肿瘤进展和转移，凸显了CEACAM5作为癌症免疫治疗靶标的重要性。CEACAM5单克隆抗体（CI-P83-1）在癌症生物学领域具有多种应用和重要作用，是肿瘤标志物和细胞粘附机制研究人员的必备工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CEACAM5 抗体 (CI-P83-1) 参考文献:

  1. 结直肠癌患者癌胚抗原基因突变：对肝转移的影响。  |  Zimmer, R. and Thomas, P. 2001. Cancer Res. 61: 2822-6. PMID: 11306451
  2. 组装和分析人类 19 号染色体 CEA 基因家族区域的宇宙等位基因。  |  Tynan, K., et al. 1992. Nucleic Acids Res. 20: 1629-36. PMID: 1579453
  3. 克隆出癌胚抗原的完整基因：对其启动子的分析表明，该区域可传递细胞类型特异性表达。  |  Schrewe, H., et al. 1990. Mol Cell Biol. 10: 2738-48. PMID: 2342461
  4. 癌胚抗原：癌胚抗原家族新成员编码的多种 mRNA 的替代剪接原因。  |  Barnett, TR., et al. 1989. J Cell Biol. 108: 267-76. PMID: 2537311
  5. 编码人类癌胚抗原的 cDNA 克隆的分离和特征研究揭示了一种高度保守的重复结构。  |  Zimmermann, W., et al. 1987. Proc Natl Acad Sci U S A. 84: 2960-4. PMID: 3033671
  6. 癌胚抗原家族：NCA 和 CEA 编码 cDNA 的特征及其保守环域非随机序列变异的提示。  |  Barnett, T., et al. 1988. Genomics. 3: 59-66. PMID: 3220478
  7. SAR408701的临床前活性：一种新型抗CEACAM5-马钱子素抗体-药物偶联物，用于治疗CEACAM5阳性上皮肿瘤。  |  Decary, S., et al. 2020. Clin Cancer Res. 26: 6589-6599. PMID: 33046521
  8. 抗CEACAM5-DM4抗体-药物偶联物tusamitamab ravtansine（SAR408701）在晚期实体瘤患者中的安全性、药代动力学和抗肿瘤活性：首次人体剂量递增研究。  |  Gazzah, A., et al. 2022. Ann Oncol. 33: 416-425. PMID: 35026412
  9. 肺癌治疗靶点的研究：癌胚抗原相关细胞粘附分子5的表达及其相关分子图谱的临床前和人体研究。  |  Lefebvre, AM., et al. 2023. Lung Cancer. 184: 107356. PMID: 37660479
  10. 缺氧外泌体衍生的CEACAM5促进肿瘤相关巨噬细胞M2极化，通过MMP9加速胰腺神经内分泌肿瘤的转移。  |  Ye, M., et al. 2024. FASEB J. 38: e23762. PMID: 38923643
  11. CD66 家族成员与人类中性粒细胞中的酪氨酸激酶活性有关。  |  Skubitz, KM., et al. 1995. J Immunol. 155: 5382-90. PMID: 7594554
  12. 人类胆汁糖蛋白基因：新型替代剪接 RNA 家族及其表达蛋白的特征。  |  Barnett, TR., et al. 1993. Mol Cell Biol. 13: 1273-82. PMID: 8423792

订购信息

产品名称产品编号规格价格数量收藏夹

CEACAM5 抗体 (CI-P83-1)

sc-23928
200 µg/ml
$316.00

CEACAM5 (CI-P83-1): m-IgGκ BP-HRP 套装

sc-520748
200 µg Ab, 40 µg BP
$354.00

CEACAM5 抗体 (CI-P83-1) AC

sc-23928 AC
500 µg/ml, 25% agarose
$416.00

CEACAM5 抗体 (CI-P83-1) HRP

sc-23928 HRP
200 µg/ml
$316.00

CEACAM5 抗体 (CI-P83-1) FITC

sc-23928 FITC
200 µg/ml
$330.00

CEACAM5 抗体 (CI-P83-1) PE

sc-23928 PE
200 µg/ml
$343.00

CEACAM5 抗体 (CI-P83-1) Alexa Fluor® 488

sc-23928 AF488
200 µg/ml
$357.00

CEACAM5 抗体 (CI-P83-1) Alexa Fluor® 546

sc-23928 AF546
200 µg/ml
$357.00

CEACAM5 抗体 (CI-P83-1) Alexa Fluor® 594

sc-23928 AF594
200 µg/ml
$357.00

CEACAM5 抗体 (CI-P83-1) Alexa Fluor® 647

sc-23928 AF647
200 µg/ml
$357.00

CEACAM5 抗体 (CI-P83-1) Alexa Fluor® 680

sc-23928 AF680
200 µg/ml
$357.00

CEACAM5 抗体 (CI-P83-1) Alexa Fluor® 790

sc-23928 AF790
200 µg/ml
$357.00

May I know what is "CEA-180" used to raise this antibody? If it is the CEACAM5 protein, how it was expressed? Thanks

Asked by: Jun Yan
Thank you for your question. CEACAM5 (CI-P83-1) is reactive in CEACAM5; non cross-reactive with CD66c, CD66a or granulocytes. Here is a link for more information on the Gene : https://www.uniprot.org/uniprotkb/P06731/entry.
Answered by: BlakeJ
Date published: 2024-09-26

Is it possible to use the HRP conjugated form sc-23928 HRP in both Western Blot and IP?

Asked by: cjMara
Thank you for your question. We actually do not recommend the use of the HRP conjugated form in IP. The unconjugated form of the antibody is the best choice when working in multiple applications that do not use the same conjugation (Agarose, Biotin, HRP, FITC, etc.).
Answered by: Technical Support 7
Date published: 2017-01-18
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Rated 5 out of 5 by from Outstanding !!Great western blot and IHC staining data; outstanding product
Date published: 2017-02-01
Rated 5 out of 5 by from Recommended for WBThis antibody is recommended for detection of CEACAM5 of mouse, rat and human origin by WB, IP, IF.
Date published: 2016-12-23
Rated 5 out of 5 by from Really satisfied with that AbReally satisfied with that Ab. Used it for both FC and WB. it works great and more importantly, it is a reliable one.
Date published: 2015-08-21
Rated 5 out of 5 by from Clean bands in western blot using human CEAClean bands in western blot using human CEA transfected 293T and T84 whole cell lysates. -SCBT QC
Date published: 2015-06-14
Rated 5 out of 5 by from Got good staining in IFGot good staining in IF, use it routinely in the lab.
Date published: 2015-06-05
Rated 5 out of 5 by from Produced great immunoperoxidase membraneProduced great immunoperoxidase membrane and cytoplasmic staining in formalin fixed, paraffin-embedded human rectum tissue. -SCBT QC
Date published: 2015-03-17
Rated 5 out of 5 by from WB publishable data with mouse AsPc1 cellsWB publishable data with mouse AsPc1 cells - SCBT Publication Review
Date published: 2015-01-09
Rated 5 out of 5 by from Produced great FCM data for TProduced great FCM data for T-84D cells. -SCBT QC
Date published: 2013-06-07
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CEACAM5 抗体 (CI-P83-1) is rated 5.0 out of 5 by 8.
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