CD84 Antibody (CD84.1.21): sc-59137

CD84 Antibody (CD84.1.21) is a mouse monoclonal IgG1 antibody that detects CD84 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD84 is a member of the immunoglobulin superfamily and plays a crucial role in immune responses by acting as a costimulatory molecule on the surface of B lymphocytes, monocytes, and platelets. CD84 is primarily located in the plasma membrane, where CD84 facilitates cell-cell interactions and enhances the activation of immune cells. This localization is vital for CD84 function, as CD84 engages with ligands and participates in signaling pathways that promote immune responses. Notably, CD84 exists in five isoforms—CD84a, CD84b, CD84c, CD84d, and CD84e—each generated through alternative splicing and exhibiting differential expression patterns. These isoforms may have distinct roles in modulating immune activity, and their specific interactions with other proteins can influence the overall immune response. The presence of potential phosphorylation sites on these isoforms suggests a mechanism for regulating CD84 activity, highlighting the importance of post-translational modifications in fine-tuning immune signaling. Anti-CD84 antibody (CD84.1.21) is an essential tool for researchers studying immune cell function and the intricate signaling networks that govern immune responses.

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CD84 Antibody (CD84.1.21) References:

1. CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1.  |  Martin, M., et al. 2001. J Immunol. 167: 3668-76. PMID: 11564780
2. CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2.  |  Tangye, SG., et al. 2002. Eur J Immunol. 32: 1640-9. PMID: 12115647
3. CD84 expression on human hematopoietic progenitor cells.  |  Zaiss, M., et al. 2003. Exp Hematol. 31: 798-805. PMID: 12962726
4. The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells.  |  Oliver-Vila, I., et al. 2008. Mol Immunol. 45: 2138-49. PMID: 18243321
5. CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells.  |  Álvarez-Errico, D., et al. 2011. J Immunol. 187: 5577-86. PMID: 22068234
6. The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.  |  Hofmann, S., et al. 2012. J Thromb Haemost. 10: 2581-92. PMID: 23025437
7. CD84 is markedly up-regulated in Kawasaki disease arteriopathy.  |  Reindel, R., et al. 2014. Clin Exp Immunol. 177: 203-11. PMID: 24635044
8. CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia.  |  Lewinsky, H., et al. 2018. J Clin Invest. 128: 5465-5478. PMID: 30277471
9. The homophilic CD84 receptor is upregulated on platelets in COVID-19 and sepsis.  |  Weiss, LJ., et al. 2022. Thromb Res. 220: 121-124. PMID: 36334399
10. Targeting CD84 protein on myeloid-derived suppressor cells as a novel immunotherapy in solid tumors.  |  Mobini, S., et al. 2025. Comput Methods Programs Biomed. 261: 108607. PMID: 39847992

The preferred CD84 antibody is CD84 Antibody (152-1D5): sc-23899.