CD26 Antibody (OX61): sc-53039
- CD26 Antibody (OX61) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against purified Ia glycoprotein of rat origin
- recommended for detection of CD26 of mouse and rat origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See CD26 (5E8): sc-52642 for CD26 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD26 Antibody (OX61) for WB applications. These reagents are now offered in bundles with CD26 Antibody (OX61) (see ordering information below).
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CD26 Antibody (OX61) is a mouse monoclonal IgG2a antibody that detects CD26 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD26, also known as dipeptidylpeptidase 4, plays a crucial role in immune regulation, acting as a T cell activation molecule and a regulator of chemokine function. This membrane glycoprotein is primarily located on the surface of various immune cells, including T lymphocytes, where CD26′s presence is vital for the formation of the immunological synapse. The interaction of CD26 with adenosine deaminase and adenosine receptors on dendritic cells enhances T cell activation, leading to increased production of proinflammatory cytokines such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-6. Furthermore, CD26′s involvement in the pathogenesis of human cancers, including both solid tumors and hematological malignancies, underscores CD26′s importance in cancer biology. The interaction between CD26 and caveolin-1 is particularly noteworthy, as CD26 facilitates the up-regulation of CD86 on monocytes, which is essential for effective antigen-specific T cell activation. Anti-CD26 antibody (OX61) is an invaluable tool for researchers investigating the complex roles of CD26 in immune responses and cancer progression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD26 Antibody (OX61) References:
- CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes. | Gorrell, MD., et al. 2001. Scand J Immunol. 54: 249-64. PMID: 11555388
- CD26/dipeptidyl peptidase IV and its role in cancer. | Pro, B. and Dang, NH. 2004. Histol Histopathol. 19: 1345-51. PMID: 15375776
- DPPIV (CD26) as a novel stem cell marker in Ph+ chronic myeloid leukaemia. | Valent, P., et al. 2014. Eur J Clin Invest. 44: 1239-45. PMID: 25371066
- CD26 a cancer stem cell marker and therapeutic target. | Davies, S., et al. 2015. Biomed Pharmacother. 71: 135-8. PMID: 25960228
- CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology. | Kawakita, E., et al. 2021. Cancers (Basel). 13: PMID: 34063285
- The influence of CD26+ and CD26- fibroblasts on the regeneration of human dermo-epidermal skin substitutes. | Michalak-Micka, K., et al. 2022. Sci Rep. 12: 1944. PMID: 35121765
- The Role of Serum CD26 in the Diagnosis of Gastric Cancer. | Lee, JY. and Park, MJ. 2022. Int J Gen Med. 15: 7179-7187. PMID: 36118182
- Depletion of polyfunctional CD26highCD8+ T cells repertoire in chronic lymphocytic leukemia. | Bozorgmehr, N., et al. 2023. Exp Hematol Oncol. 12: 13. PMID: 36707896
- CD26 CAR-T cells have attenuated mitochondrial and glycolytic metabolic profiling. | Zhu, X., et al. 2023. Immunopharmacol Immunotoxicol. 45: 709-718. PMID: 37382435
- Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies. | Kobayashi, E., et al. 2023. Cells. 12: PMID: 37626869
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD26 Antibody (OX61) | sc-53039 | 200 µg/ml | $322.00 | |||
CD26 Antibody (OX61): m-IgG Fc BP-HRP Bundle | sc-536876 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD26 Antibody (OX61): m-IgGκ BP-HRP Bundle | sc-534044 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD26 Antibody (OX61) FITC | sc-53039 FITC | 200 µg/ml | $336.00 | |||
CD26 Antibody (OX61) PE | sc-53039 PE | 200 µg/ml | $349.00 |