c-Fms/CSF-1R Antibody (D-8): sc-365719

c-Fms/CSF-1R Antibody (D-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects c-Fms/CSF-1R in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-c-Fms/CSF-1R antibody (D-8) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. c-Fms/CSF-1R, also known as macrophage colony-stimulating factor receptor (M-CSFR), FIM2, or CD115, is a transmembrane tyrosine kinase receptor that plays a crucial role in the growth and differentiation of myeloid cells. c-Fms/CSF-1R is encoded by the c-Fms proto-oncogene and is predominantly expressed in mononuclear phagocytes, oocytes, decidual cells, trophoblastic cells, and certain myoblasts. c-Fms/CSF-1R mediates the functions of M-CSF, a glycoprotein essential for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF is a significant player in the inflammatory response, regulating the release of pro-inflammatory cytokines from macrophages, thereby influencing immune responses and tissue homeostasis. Understanding c-Fms/CSF-1R in these processes is vital for developing therapeutic strategies targeting inflammatory diseases and disorders related to myeloid cell function.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-Fms/CSF-1R Antibody (D-8) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-c-Fms/CSF-1R Antibody (D-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-Fms/CSF-1R Antibody (D-8) Specifications

Alternate Product Name: c-Fms/CSF-1R

Product Clone Name: D-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 943-971

Epitope Target: c-Fms/CSF-1R

Epitope Species: human

Product Reactivity/Detection: c-Fms/CSF-1R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for c-Fms/CSF-1R Antibody (D-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred c-Fms/CSF-1R antibody is c-Fms/CSF-1R Antibody (B-8): sc-46662.