Btk Antibody (DFS): sc-81735
- Btk Antibody (DFS) is a mouse monoclonal IgG2a κ, cited in 6 publications, provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 212-275 (SH3 domain) of Btk of human origin
- recommended for detection of Btk of mouse, rat and human origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See Btk (E-9): sc-28387 for Btk antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Btk Antibody (DFS) for WB applications. These reagents are now offered in bundles with Btk Antibody (DFS) (see ordering information below).
QUICK LINKS
SEE ALSO...
Btk Antibody (DFS) is a mouse monoclonal IgG2a antibody that detects Bruton′s tyrosine kinase (Btk) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Btk plays a crucial role in B cell development and signaling, making Btk essential for the immune response. Mutations in the Btk gene can lead to X-linked agammaglobulinemia, a condition characterized by a significant reduction in B cells and immunoglobulins, which leaves individuals susceptible to infections. Btk is primarily located in the cytoplasm and becomes activated upon B cell receptor engagement, leading to downstream signaling that promotes cell survival and proliferation. Understanding the function and regulation of Btk is vital for developing targeted therapies for immunodeficiencies and certain types of cancers, as Btk dysregulation can contribute to malignancies. Anti-Btk antibody (DFS) serves as an invaluable tool for researchers studying B cell biology and related pathologies, providing reliable detection and characterization of Btk.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Btk Antibody (DFS) | sc-81735 | 200 µg/ml | $322.00 | |||
Btk Antibody (DFS): m-IgG Fc BP-HRP Bundle | sc-539660 | 200 µg Ab; 10 µg BP | $361.00 | |||
Btk Antibody (DFS): m-IgG2a BP-HRP Bundle | sc-546744 | 200 µg Ab; 10 µg BP | $361.00 | |||
Btk Antibody (DFS) FITC | sc-81735 FITC | 200 µg/ml | $336.00 | |||
Btk Antibody (DFS) PE | sc-81735 PE | 200 µg/ml | $349.00 |