Molecular structure of Bcl-2 Inhibitor, CAS Number: 383860-03-5
Bcl-2 Inhibitor (CAS 383860-03-5)
Application:
Bcl-2 Inhibitor is a potent cell-permeable Bcl-2 inhibitor
CAS Number:
383860-03-5
Purity:
≥97%
Molecular Weight:
300.3
Molecular Formula:
C16H16N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
This contains a mixture of two tautomers (A and B). A potent, cell-permeable, Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-x in vitro (IC50 10 µM and 7 µM, respectively). It also reduces cell viability and growth in HL-60 cell lines with high Bcl-2 expression (IC50= 4 µM). Also induces apoptosis in a dose-dependent manner in cancer cells exhibiting high Bcl-2 expression with little effect on cancer cells with low Bcl-2 expression.
Bcl-2 Inhibitor (CAS 383860-03-5) References
- Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. | Enyedy, IJ., et al. 2001. J Med Chem. 44: 4313-24. PMID: 11728179
- Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. | Slater, LH., et al. 2013. ACS Chem Biol. 8: 812-22. PMID: 23343607
Inhibitor of:
Aftiphilin, and Bcl-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-2 Inhibitor, 5 mg | sc-221286 | 5 mg | $539.00 |