Date published: 2025-9-8

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Bag-1 抗体 (F-7): sc-25296

5.0(5)
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说明书
  • Bag-1抗体(F-7)是小鼠单克隆IgG1 κ, 在2篇文献中引用,规格为200 µg/ml
  • 免疫human物种的Bag-1的氨基酸73-274
  • 推荐用于 human 来源的Bag-1 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 Bag-1 抗体 (F-7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Bag-1 抗体 (F-7) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Bcl-2蛋白家族的特征是能在广泛的生理条件下调节细胞死亡(凋亡)。Bcl-2和几种相关蛋白的功能是抑制凋亡,而Bcl-2家族的其他成员,如Bax和Bak,则在各种条件下促进细胞死亡。例如,Bcl-xL抑制细胞死亡,而其较短的形式Bcl-xS则促进凋亡。这个家族中另一个成员Bad与Bcl-xL形成二聚体,导致Bax从Bcl-xL/Bax复合物中解离,并恢复Bax介导的凋亡。一种Bcl-2结合蛋白,被命名为Bag-1,它与Bcl-2或其他Bcl-2相关蛋白没有显著的同源性。Bag-1似乎可以增强Bcl-2对细胞死亡的保护作用,这表明Bag-1代表了一种新型的抗细胞死亡基因。这也表明,一些以前归因于Bcl-2独立途径的凋亡诱导途径,可能实际上反映了Bcl-2和Bag-1结合的需求。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Bag-1 抗体 (F-7) 参考文献:

  1. BAG-1辅助蛋白家族在核受体作用调节中的作用。  |  Cato, AC. and Mink, S. 2001. J Steroid Biochem Mol Biol. 78: 379-88. PMID: 11738548
  2. BAG-1在人类癌症中的表达和功能。  |  Cutress, RI., et al. 2002. Br J Cancer. 87: 834-9. PMID: 12373595
  3. BAG-1在癌变中的作用。  |  Sharp, A., et al. 2004. Expert Rev Mol Med. 6: 1-15. PMID: 15033003
  4. 口腔鳞状细胞癌中的Bag-1蛋白。  |  Wood, J., et al. 2009. Oral Oncol. 45: 94-102. PMID: 18804403
  5. BAG-1作为早期乳腺癌预后的生物标志物:系统综述与荟萃分析  |  Papadakis, ES., et al. 2017. Br J Cancer. 116: 1585-1594. PMID: 28510570
  6. 皮质酮刺激后,BAG-1介导糖皮质激素受体转运至线粒体:在调节情绪恢复方面的潜在作用。  |  Luo, S., et al. 2021. J Neurochem. 158: 358-372. PMID: 33025573
  7. 辅助伴侣 Bag-1 通过 Beclin 1 相互作用在依赖自噬的细胞存活中发挥作用  |  Turk, M., et al. 2021. Molecules. 26: PMID: 33561998
  8. CRISPR/Cas9 介导的 Bag-1 基因敲除可通过 Akt 过度激活介导的肌动蛋白细胞骨架重塑增加 MCF-7 细胞的间质特征。  |  Kilbas, PO., et al. 2022. PLoS One. 17: e0261062. PMID: 34995286
  9. Bag-1通过与HSP70相互作用保护髓核细胞免受氧化应激。  |  Suyama, K., et al. 2023. Biomedicines. 11: PMID: 36979842
  10. 褪黑素、BAG-1和皮质醇在肿瘤发病机理和免疫反应模式中的昼夜节律相互作用。  |  Anderson, G. 2023. Explor Target Antitumor Ther. 4: 962-993. PMID: 37970210

订购信息

产品名称产品编号规格价格数量收藏夹

Bag-1 抗体 (F-7)

sc-25296
200 µg/ml
$316.00

Bag-1 (F-7): m-IgG Fc BP-HRP 套装

sc-536703
200 µg Ab; 10 µg BP
$354.00

Bag-1 (F-7): m-IgGκ BP-HRP 套装

sc-533863
200 µg Ab; 40 µg BP
$354.00

Bag-1 (F-7): m-IgG1 BP-HRP 套装

sc-544773
200 µg Ab; 20 µg BP
$354.00

Can Bag-1 (F-7): sc-25296 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Randy McDonald
Thank you for your question. Yes, Bag-1 (F-7): sc-25296 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Good specificity in WB in transfected HeLa cellsGood specificity in WB in transfected HeLa cells. -SCBT QC
Date published: 2015-07-18
Rated 5 out of 5 by from Positive signal in WB in human transfectedPositive signal in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-04-06
Rated 5 out of 5 by from Strong signal strength in WB in HLStrong signal strength in WB in HL-60 whole cell lysate. -SCBT QC
Date published: 2015-04-03
Rated 5 out of 5 by from Strong band in WB in HeLa and Jurkat wholeStrong band in WB in HeLa and Jurkat whole cell lysates. -SCBT QC
Date published: 2015-04-03
Rated 5 out of 5 by from Excellent immunoperoxidase cytoplasmic andExcellent immunoperoxidase cytoplasmic and nuclear staining in formalin fixed, paraffin-embedded human breast tissue. -SCBT QC
Date published: 2015-01-28
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Bag-1 抗体 (F-7) is rated 5.0 out of 5 by 5.
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