Date published: 2025-9-9

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ASC-1 抗体 (D-4): sc-365611

5.0(4)
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说明书
  • ASC-1抗体(D-4)是小鼠单克隆IgG1 κ, 在5篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的ASC-1的N-terminus附近的氨基酸1-27之间
  • 推荐用于 mouse, rat 和 human 来源的ASC-1 WB, IP, IF 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-365611 X, 200 µg/0.1 ml)
  • 1 BP-HRP">m-IgG1 BP-HRP是ASC-1 Antibody (D-4) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与ASC-1 Antibody (D-4) 打包提供(请参阅下面的订购信息)。

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関連項目

激活信号共整合子-1(ASC-1),最初被鉴定为TRIP4,是与RNA聚合酶II复合物的特定组分相关的核受体的转录共激活子,并结合基础转录因子TBP和TFIIA。 ASC-1通过其锌指基序与转录整合子SRC-1和CBP/p300一起发挥作用,并依赖于它们的配体依赖性转录激活域AF2。 HeLa细胞中的内源性ASC-1主要是核蛋白。在血清饥饿的条件下,ASC-1定位于细胞质中。然而,当在共表达的CBP或SRC-1的配体存在下血清饥饿时,ASC-1仍留在细胞核中。 ASC-1的这种行为表明,它可能在不同的细胞条件下建立不同的共激活子复合物中发挥重要作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ASC-1 抗体 (D-4) 参考文献:

  1. 谷氨酸转运蛋白1(asc-1)在啮齿动物大脑中的分布和药理学。  |  Helboe, L., et al. 2003. Eur J Neurosci. 18: 2227-38. PMID: 14622183
  2. 胃泌素激活旁分泌网络,通过MAZ和Asc-1诱导PAI-2。  |  Almeida-Vega, S., et al. 2009. Am J Physiol Gastrointest Liver Physiol. 296: G414-23. PMID: 19074642
  3. 转录辅激活子 Asc-1 是骨骼肌生成的调节因子,缺乏它会导致一种新型先天性肌肉疾病。  |  Davignon, L., et al. 2016. Hum Mol Genet. 25: 1559-73. PMID: 27008887
  4. 星形胶质细胞转运蛋白SLC7A10(Asc-1)介导脊髓运动神经元的甘氨酸抑制。  |  Ehmsen, JT., et al. 2016. Sci Rep. 6: 35592. PMID: 27759100
  5. 丙氨酸-丝氨酸-半胱氨酸转运蛋白(SLC7A10,Asc-1)在神经元中发挥甘氨酸抑制性传递和呼吸模式的作用。  |  Mesuret, G., et al. 2018. Sci Rep. 8: 8536. PMID: 29867218
  6. Asc-1 复合物分解碰撞的核糖体  |  Juszkiewicz, S., et al. 2020. Mol Cell. 79: 603-614.e8. PMID: 32579943
  7. Asc-1调节皮下基质细胞群体中白色与米色脂肪细胞的命运。  |  Suwandhi, L., et al. 2021. Nat Commun. 12: 1588. PMID: 33707431
  8. 人体脂肪细胞对肾上腺素刺激的高效产热反应需要依赖Asc-1转运蛋白的氨基酸摄取。  |  Arianti, R., et al. 2021. FEBS Lett. 595: 2085-2098. PMID: 34197627
  9. 在实验性帕金森症和左旋多巴诱导的运动障碍模型小鼠中,基底神经节中氨基酸转运蛋白Asc-1(SLC7A10)的表达发生了变化。  |  Nakahara, K., et al. 2023. J Chem Neuroanat. 127: 102191. PMID: 36403747
  10. Asc-1复合物通过扫描核糖体促进翻译起始。  |  Kito, Y., et al. 2023. EMBO J. 42: e112869. PMID: 37092320

订购信息

产品名称产品编号规格价格数量收藏夹

ASC-1 抗体 (D-4)

sc-365611
200 µg/ml
$316.00

ASC-1 (D-4): m-IgG1 BP-HRP 套装

sc-542693
200 µg Ab; 20 µg BP
$354.00

ASC-1 (D-4) 中和勝肽

sc-365611 P
100 µg/0.5 ml
$68.00

ASC-1 抗体 (D-4) X

sc-365611 X
200 µg/0.1 ml
$316.00

What application is the blocking peptide sc-365611 P appropriate for?

Asked by: Germaine
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-03-01
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Rated 5 out of 5 by from Western BlotUsed in Western Blot for the detection of ASC-1 at a working dilution 1:500. Incubation for 1.5hrs at RT. Very specific (compared with abcam's same protein antibody) and strong signal.
Date published: 2017-07-23
Rated 5 out of 5 by from strong bandSuitalbe for WB detect of ASC-1 ,very good binding the target protein, shows strong signal and no background.
Date published: 2017-06-03
Rated 5 out of 5 by from Produced positive Western Blot data of AexpressionProduced positive Western Blot data of Aexpression in HeLa and K-562 whole cell lysates. -SCBT QC
Date published: 2015-04-29
Rated 5 out of 5 by from Produced positive Western Blot data of AexpressionProduced positive Western Blot data of Aexpression in non-transfected and mouse Atransfected 293T whole cell lysates. -SCBT QC
Date published: 2014-10-07
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ASC-1 抗体 (D-4) is rated 5.0 out of 5 by 4.
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