Date published: 2025-9-7

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Aquaporin 8/AQP8 抗体 (14-Z): sc-81870

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说明书
  • Aquaporin 8/AQP8 抗体 14-Z 是小鼠单克隆 IgG2a κ,Aquaporin 8/AQP8抗体, 在6篇文献中引用,规格为100 µg/ml
  • 与全长重组蛋白反应,该蛋白与human的AQP8的氨基酸1-256对应
  • 推荐用于 mouse, rat 和 human 来源的AQP8 WB, IP 和 ELISA检测
  • 关于如何获取Aquaporin 8/AQP8 (14-Z): sc-81870免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成Aquaporin 8/AQP8 抗体 (14-Z)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

AQP8抗体(14-Z)是IgG2a κ小鼠单克隆AQP8抗体(也称为水通道蛋白8抗体),通过WB、IP和ELISA检测小鼠、大鼠和人源AQP8蛋白。AQP8抗体(14-Z)可提供非偶联的抗AQP8抗体。人水通道蛋白8 (Aquaporin 8, AQP8)是由261个氨基酸组成的蛋白质,包含6个跨膜结构域、2个主要内源蛋白家族成员特有的保守的asn-pro-ala (NPA)基序和3个N-连接的糖基化位点。水通道蛋白(AQPs)是整体膜水转运通道蛋白,促进水的转运通过细胞膜的大家族。这种功能在动物、植物和细菌中是保守的。水通道蛋白在哺乳动物中有多种亚型,被命名为AQP0 - AQP10。水通道蛋白分布广泛,同一细胞内存在多种水通道蛋白并不少见。虽然大多数水通道蛋白仅对水具有通透性,但AQP3, AQP7, AQP9和两个AQP10转录本中的一个也对尿素和甘油具有通透性。水通道蛋白参与肾脏的吸水、肺分泌物的产生、流泪以及脑脊液和房水的分泌和重吸收。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Aquaporin 8/AQP8 抗体 (14-Z) 参考文献:

  1. 哺乳动物水通道蛋白家族:有希望的新药靶点  |  Beitz, E. and Schultz, JE. 1999. Curr Med Chem. 6: 457-67. PMID: 10213793
  2. 将 aquaporin-8 水通道基因(AQP8)分配到人类染色体 16p12。  |  Viggiano, L., et al. 1999. Cytogenet Cell Genet. 84: 208-10. PMID: 10393433
  3. 上皮性卵巢肿瘤中 AQP6 和 AQP8 的表达。  |  Ma, J., et al. 2016. J Mol Histol. 47: 129-34. PMID: 26779650
  4. AQP8 通过下调 PI3K/AKT 信号和 PCDH7 的表达抑制结直肠癌的生长和转移。  |  Wu, Q., et al. 2018. Am J Cancer Res. 8: 266-279. PMID: 29511597
  5. 鉴定与结直肠癌侵袭性特征相关的 AQP8-miR-92a 网络。  |  Zhang, H., et al. 2020. Biochem Biophys Res Commun. 527: 218-225. PMID: 32446370
  6. AQP8通过调节颗粒细胞的凋亡参与雌激素介导的水牛卵泡发育。  |  Cao, L., et al. 2021. Reprod Domest Anim. 56: 812-820. PMID: 33639021
  7. AQP8 是产生胰岛素的 RINm5F 细胞中一个重要的 H2O2 转运体。  |  Krüger, C., et al. 2021. Redox Biol. 43: 101962. PMID: 33892285
  8. AQP8可能通过调节GSK-3β磷酸化和β-catenin的核运输来影响胶质瘤的增殖和生长。  |  Cai, Z., et al. 2023. Int J Dev Neurosci. 83: 333-345. PMID: 37081713
  9. AQP8 可能通过 ROS/PTEN/AKT 信号通路促进胶质瘤的增殖和生长。  |  Hao, Z., et al. 2023. BMC Cancer. 23: 516. PMID: 37280594
  10. 一种仅在人类肾脏中表达的新型水通道的 cDNA 克隆和基因结构:染色体 12q13 位点水蒸发蛋白基因簇的证据。  |  Ma, T., et al. 1996. Genomics. 35: 543-50. PMID: 8812490
  11. 人水肿素 8 cDNA 的克隆和功能表达及其基因分析。  |  Koyama, N., et al. 1998. Genomics. 54: 169-72. PMID: 9806845
  12. 水通道蛋白。  |  Echevarría, M. and Ilundáin, AA. 1998. J Physiol Biochem. 54: 107-18. PMID: 9858131

订购信息

产品名称产品编号规格价格数量收藏夹

Aquaporin 8/AQP8 抗体 (14-Z)

sc-81870
100 µg/ml
$333.00

Es posible hace citometría de flujo con este anticuerpo ?

Asked by: Yaya
Gracias por su pregunta. Se recomienda el anticuerpo Aquaporina 8/AQP8 para la detección de AQP8 de origen murino, de rata y humano mediante WB, IP y ELISA.
Answered by: BlakeJ
Date published: 2025-06-23

Hi, I am working on E coli Aquaporin Z (UNIPROT ID P60844). Do you have any antibody that is anti-aqpZ? Or at least have cross reactivity to bind to aqpZ? Thanks.

Asked by: Jason N
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2022-10-12

Buenos días, soy François Chauvigne, investigador en el IRTA (Barcelona, Espana), y me preguntaba si podríamos tener un alícuota del anticuerpo AQP8 (14-Z): sc-81870, para probar si reacciona en nuestras muestras. Muchas gracias, François Chauvigne

Asked by: Francois
Muchas gracias por su pregunta. Por favor, envíenos un email a spain@scbt.com con la siguiente información: - dirección completa para el envío (incluyendo el nombre del grupo y del PI) - número de teléfono y de fax, además de una dirección de e-mail - nombre de la persona a la cual debemos enviarle los productos - número de catálogo del producto y su descripción correspondiente
Answered by: Technical Support Europe
Date published: 2018-01-18

For Western Blot, is it recommended to use denatured or non-denatured conditions with AQP8 (14-Z): sc-81870 antibody?

Asked by: jenniferc
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 4 out of 5 by from Good antibody!I have a good result in placental tissue. Little baclground and good specificity.
Date published: 2018-05-29
Rated 4 out of 5 by from goodI received the antibody about 6 months ago. I tested it in WB using sperm cells and Hela. One faint band was observed in sperm but a good band in Hela. The size is that expected.
Date published: 2017-07-11
Rated 5 out of 5 by from Single band at 34 kDaGood choice for detecting AQP8 in Western Blot, shows a single band around the expected weight of 34 kDa.
Date published: 2017-02-06
Rated 5 out of 5 by from Good specificity in WB in mouse 293T wholeGood specificity in WB in mouse 293T whole cell lysates. -SCBT QC
Date published: 2015-02-27
Rated 5 out of 5 by from Worked well in WB in HeLa nuclear extractWorked well in WB in HeLa nuclear extract. -SCBT QC
Date published: 2015-02-08
Rated 5 out of 5 by from Single strong band in WB in HeLa whole cell lysateSingle strong band in WB in HeLa whole cell lysate. -SCBT QC
Date published: 2015-01-31
Rated 5 out of 5 by from Strong band in WB in PCStrong band in WB in PC-12 and PANC-1 whole cell lysates. -SCBT QC
Date published: 2014-04-28
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Aquaporin 8/AQP8 抗体 (14-Z) is rated 4.7 out of 5 by 7.
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