Aquaporin 8/AQP8 Antibody (14-Z): sc-81870

AQP8 Antibody (14-Z) is a mouse monoclonal IgG2a kappa light chain antibody that detects AQP8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-AQP8 antibody (14-Z) is available as the non-conjugated form. AQP8, also known as aquaporin 8, is a 261 amino acid integral membrane protein characterized by six membrane-spanning domains and two conserved asparagine-proline-alanine (NPA) motifs, which are essential for water channel function. AQP8 plays a critical role in facilitating water transport across cell membranes, a function vital for maintaining cellular homeostasis and regulating osmotic balance in various tissues. AQP8 is particularly important in the kidneys, where AQP8 contributes to water reabsorption, and in the gastrointestinal tract, where AQP8 aids in digestive fluid secretion. AQP8 has been implicated in the transport of other small solutes, which may influence various physiological processes. Three N-linked glycosylation sites on AQP8 suggest that post-translational modifications may play a role in stability and function, potentially affecting protein interactions and overall cellular activity.

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Aquaporin 8/AQP8 Antibody (14-Z) References:

1. The mammalian aquaporin water channel family: A promising new drug target.  |  Beitz, E. and Schultz, JE. 1999. Curr Med Chem. 6: 457-67. PMID: 10213793
2. Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12.  |  Viggiano, L., et al. 1999. Cytogenet Cell Genet. 84: 208-10. PMID: 10393433
3. Expression of AQP6 and AQP8 in epithelial ovarian tumor.  |  Ma, J., et al. 2016. J Mol Histol. 47: 129-34. PMID: 26779650
4. AQP8 inhibits colorectal cancer growth and metastasis by down-regulating PI3K/AKT signaling and PCDH7 expression.  |  Wu, Q., et al. 2018. Am J Cancer Res. 8: 266-279. PMID: 29511597
5. Identification of the AQP8-miR-92a network associated with the aggressive traits of colorectal cancer.  |  Zhang, H., et al. 2020. Biochem Biophys Res Commun. 527: 218-225. PMID: 32446370
6. AQP8 participates in oestrogen-mediated buffalo follicular development by regulating apoptosis of granulosa cells.  |  Cao, L., et al. 2021. Reprod Domest Anim. 56: 812-820. PMID: 33639021
7. AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F cells.  |  Krüger, C., et al. 2021. Redox Biol. 43: 101962. PMID: 33892285
8. AQP8 may affect glioma proliferation and growth by regulating GSK-3β phosphorylation and nuclear transport of β-catenin.  |  Cai, Z., et al. 2023. Int J Dev Neurosci. 83: 333-345. PMID: 37081713
9. AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway.  |  Hao, Z., et al. 2023. BMC Cancer. 23: 516. PMID: 37280594
10. cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13.  |  Ma, T., et al. 1996. Genomics. 35: 543-50. PMID: 8812490
11. Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene.  |  Koyama, N., et al. 1998. Genomics. 54: 169-72. PMID: 9806845
12. Aquaporins.  |  Echevarría, M. and Ilundáin, AA. 1998. J Physiol Biochem. 54: 107-18. PMID: 9858131

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aquaporin 8/AQP8 Antibody (14-Z) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Aquaporin 8/AQP8 Antibody (14-Z) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aquaporin 8/AQP8 Antibody (14-Z) Specifications

Alternate Product Name: aquaporin 8

Product Clone Name: 14-Z

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-256

Epitope Target: AQP8

Epitope Species: human

Product Reactivity/Detection: AQP8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Aquaporin 8/AQP8 Antibody (14-Z): N/A