Date published: 2025-9-6

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AP-2γ 抗体 (AP2g 6E4/4): sc-53162

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说明书
  • AP-2γ抗体(AP2g 6E4/4)是小鼠单克隆IgG1 κ, 在5篇文献中引用,规格为200 µg/ml
  • 针对human起源的细菌AP-2α/AP-2α/AP-2γ融合蛋白
  • 推荐用于 mouse, rat 和 human 来源的AP-2γ WB, IP, IF 和 IHC(P)检测
  • 看 AP-2γ (6E4/4): sc-12762,可查看有标记的 AP-2γ 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 AP-2γ 抗体 (AP2g 6E4/4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与AP-2γ 抗体 (AP2g 6E4/4) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

AP-2γ抗体(AP2g 6E4/4)是一种小鼠单克隆IgG1κ轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和免疫组织化学检测小鼠、大鼠和人类来源的AP-2γ蛋白。AP-2γ是AP-2转录因子家族的重要成员,该家族还包括AP-2α和AP-2β,可与DNA的CCCAGGC序列结合,启动特定基因的转录。AP-2γ蛋白主要位于细胞核中,AP-2γ (AP2g 6E4/4)抗体在调节与细胞生长和分化相关的基因表达方面发挥着重要作用。AP-2γ的核定位对于其作为转录因子的功能至关重要,它能够与各种基因启动子相互作用,并调节参与关键细胞过程的基因的表达。AP-2γ单克隆抗体(AP2g 6E4/4)有助于研究人员研究AP-2γ在调节原癌基因c-ErbB-2中的作用,该基因在许多乳腺癌中过度表达。此外,AP-2γ是OB2-1转录因子复合物的一部分,可影响与肿瘤发生相关的基因。了解AP-2γ的功能和定位对于阐明其在正常细胞过程和疾病状态中的作用至关重要,因此抗AP-2γ抗体(AP2g 6E4/4)成为研究基因调控和癌症生物学的研究人员的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

AP-2γ 抗体 (AP2g 6E4/4) 参考文献:

  1. 人滋养细胞分化过程中 AP-2gamma 和 AP-2alpha 的差异表达。  |  Richardson, BD., et al. 2001. Life Sci. 69: 2157-65. PMID: 11669459
  2. AP-2alpha 和 AP-2gamma 是 p53 在人类乳腺癌细胞中的转录靶标。  |  Li, H., et al. 2006. Oncogene. 25: 5405-15. PMID: 16636674
  3. AP-2gamma 能诱导 p21 的表达,阻止细胞周期,抑制人类癌细胞的肿瘤生长。  |  Li, H., et al. 2006. Neoplasia. 8: 568-77. PMID: 16867219
  4. AP-2γ 调节雌激素受体介导的长程染色质相互作用和基因转录。  |  Tan, SK., et al. 2011. EMBO J. 30: 2569-81. PMID: 21572391
  5. 大鼠睾丸中 Ap-2γ 表达的发生过程  |  Hou, M., et al. 2011. Sex Dev. 5: 188-96. PMID: 21654158
  6. 先兆子痫患者和吸烟者胎盘中 AP-2γ 的表达。  |  Schneider, HA., et al. 2015. Arch Gynecol Obstet. 291: 1015-21. PMID: 25315380
  7. 鉴定具有促进细胞凋亡活性的基于 Wells-Dawson 多氧化金属盐的 AP-2γ 抑制剂。  |  Hu, J., et al. 2018. Biochem J. 475: 1965-1977. PMID: 29760237
  8. WWOX 在高级别膀胱癌中失去调控致癌 AP-2γ 的能力并与肿瘤抑制因子 AP-2α 协同作用  |  Kołat, D., et al. 2021. Cancers (Basel). 13: PMID: 34204827
  9. 确定 WWOX 在调节 AP-2α 和 AP-2γ 转录因子激活的膀胱癌细胞通路中的功能  |  Kołat, D., et al. 2022. Cells. 11: PMID: 35563688
  10. HN1L/AP-2γ/PLK1信号驱动食管鳞状细胞癌的肿瘤进展和化疗耐药性。  |  Zeng, TT., et al. 2022. Cell Death Dis. 13: 1026. PMID: 36476988

订购信息

产品名称产品编号规格价格数量收藏夹

AP-2γ 抗体 (AP2g 6E4/4)

sc-53162
200 µg/ml
$316.00

AP-2γ (AP2g 6E4/4): m-IgG Fc BP-HRP 套装

sc-536900
200 µg Ab; 10 µg BP
$354.00

AP-2γ (AP2g 6E4/4): m-IgGκ BP-HRP 套装

sc-534072
200 µg Ab; 40 µg BP
$354.00

AP-2γ (AP2g 6E4/4): m-IgG1 BP-HRP 套装

sc-544885
200 µg Ab; 20 µg BP
$354.00

I am using AP-2γ (AP2g 6E4/4): sc-53162 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Dr Ninau Qelp
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Good WB publishable data gathered with H1229 cellsGood WB publishable data gathered with H1229 cells. -SCBT Publication Review
Date published: 2015-06-15
Rated 4 out of 5 by from faint bands seen in WB when using MDAfaint bands seen in WB when using MDA-MB-468 and MCF7 whole cell lysates and SK-BR-3 and MCF7 nuclear extracts. -SCBT QC
Date published: 2015-05-26
Rated 5 out of 5 by from Published data for IP and WB in shTFAP2CPublished data for IP and WB in shTFAP2C-MCF-7 and H1299 cells -SCBT Publication Review
Date published: 2015-05-22
Rated 5 out of 5 by from Beautiful immunoperoxidase nuclear stainingBeautiful immunoperoxidase nuclear staining in formalin fixed, paraffin-embedded human testis cancer tissue. -SCBT QC
Date published: 2015-03-21
Rated 4 out of 5 by from Large WB bands seen using this antibody againstLarge WB bands seen using this antibody against human AP-2 transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-03-06
Rated 5 out of 5 by from Great WB signal obtained using HeLa wholeGreat WB signal obtained using HeLa whole cell lysate. -SCBT QC
Date published: 2015-01-13
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AP-2γ 抗体 (AP2g 6E4/4) is rated 4.7 out of 5 by 6.
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