Date published: 2026-10-19

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Ah Receptor 抗体 (C-4): sc-74572

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说明书
  • Ah Receptor抗体(C-4)是小鼠单克隆IgG2b κ, 在2篇文献中引用,规格为200 µg/ml
  • 免疫human物种的Ah Receptor的氨基酸637-848
  • 推荐用于 mouse, rat 和 human 来源的Ah Receptor WB, IP, IF, IHC(P) 和 ELISA检测
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-74572 X, 200 µg/0.1 ml)
  • 2b BP-HRP">m-IgG2b BP-HRP是Ah Receptor Antibody (C-4) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与Ah Receptor Antibody (C-4) 打包提供(请参阅下面的订购信息)。
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2,3,7,8-四氯二苯并二噁英(TCDD)是毒性卤代芳香族化合物家族的原型,被认为会导致不利的生殖、免疫和代谢影响。对TCDD的许多生物反应是通过配体与芳香烃(Ah)受体结合来介导的,该受体也称为AhR。 Ah受体是一种配体依赖性转录因子,与特定的DNA序列相互作用,称为外源性应答元件(XRE),位于TCDD诱导基因的上游。在与配体结合后,Ah受体与Ah受体核转运子(Arnt)结合,复合物从细胞质转移到细胞核。 Arnt是Ah受体与XRE结合所必需的。 Ah受体和Arnt是转录因子家族的成员,包含一个基本螺旋-环-螺旋基序和一个常见的"PAS"基序。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Ah Receptor 抗体 (C-4) 参考文献:

  1. 配体结合和激活Ah受体。  |  Denison, MS., et al. 2002. Chem Biol Interact. 141: 3-24. PMID: 12213382
  2. 饮食中的植物化学物质与化学预防相关,可激活耦合的Ah受体和Nrf2基因电池。  |  Köhle, C. and Bock, KW. 2006. Biochem Pharmacol. 72: 795-805. PMID: 16780804
  3. 对Ah受体和Cyp1a1基因表达的遗传和分子分析。  |  Hankinson, O., et al. 1991. Biochimie. 73: 61-6. PMID: 1851644
  4. 多环芳烃对肝癌27培养细胞增殖的Ah受体非依赖性刺激。  |  Volkov, MS., et al. 2012. Biochemistry (Mosc). 77: 201-7. PMID: 22348481
  5. Ah受体信号传导控制心脏发育和稳态基因的表达。  |  Carreira, VS., et al. 2015. Toxicol Sci. 147: 425-35. PMID: 26139165
  6. Ah受体通路的复杂性;通过不同蛋白伴侣和DNA-Motifs的信号传导。  |  Jackson, DP., et al. 2015. Toxicol Res (Camb). 4: 1143-1158. PMID: 26783425
  7. 从二噁英毒性到人类Ah受体在干细胞/祖细胞稳态中的推定生理功能。  |  Bock, KW. 2017. Biochem Pharmacol. 123: 1-7. PMID: 27349986
  8. 配体激活Ah受体有助于维持胃肠道的稳态。  |  Murray, IA. and Perdew, GH. 2017. Curr Opin Toxicol. 2: 15-23. PMID: 28944314
  9. 芳香烃(Ah)受体介导的基因表达的细胞和分子生物学。  |  Safe, S. and Krishnan, V. 1995. Arch Toxicol Suppl. 17: 99-115. PMID: 7786196
  10. Ah 受体:2,3,7,8-四氯二苯并对二恶英(TCDD)及相关化合物毒性的媒介。  |  Okey, AB., et al. 1994. Toxicol Lett. 70: 1-22. PMID: 8310450

订购信息

产品名称产品编号规格价格数量收藏夹

Ah Receptor 抗体 (C-4)

sc-74572
200 µg/ml
$322.00

Ah Receptor (C-4): m-IgG2b BP-HRP 套装

sc-548463
200 µg Ab; 10 µg BP
$361.00

Ah Receptor 抗体 (C-4) X

sc-74572 X
200 µg/0.1 ml
$322.00

When should the TransCruz reagent sc-74572 X be used instead of the standard form sc-74572?

Asked by: DefinitelyNotMatt
Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by JT from Beautiful immunoperoxidase cytoplasmic stainingBeautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human urinary bladder tissue. -SCBT QC
Date published: 2015-05-02
Rated 5 out of 5 by JT from Great antibody for WesternGreat antibody for Western, strong bands detected in Hep G2 and MCF7 whole cell lysates. -SCBT QC
Date published: 2015-03-31
Rated 4 out of 5 by JM from Favorable band achieved using HeLa wholeFavorable band achieved using HeLa whole cell lysate. -SCBT QC
Date published: 2015-03-02
Rated 5 out of 5 by SH from Great WB data obtained using mouse Ah ReceptorGreat WB data obtained using mouse Ah Receptor transfected 293 and PC-3 whole cell lysates. -SCBT QC
Date published: 2015-01-19
Rated 4 out of 5 by HC from Very large WB signal seen with PCVery large WB signal seen with PC-3 whole cell lysate. -SCBT QC
Date published: 2015-01-03
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Ah Receptor 抗体 (C-4) is rated 4.6 out of 5 by 5.
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