Date published: 2026-10-19

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Ah Receptor 抗体 (A-2): sc-398877

5.0(2)
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说明书
  • Ah Receptor抗体(A-2)是小鼠单克隆IgG1 κ, 在5篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于mouse物种的Ah Receptor的C-terminus的氨基酸767-800之间
  • 推荐用于 mouse 和 rat 来源的Ah Receptor WB, IP, IF, IHC(P) 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-398877 X, 200 µg/0.1 ml)
  • 看 Ah Receptor (A-3): sc-133088,可查看有标记的 Ah Receptor 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Ah Receptor Antibody (A-2) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Ah Receptor Antibody (A-2) 打包提供(请参阅下面的订购信息)。
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2,3,7,8-四氯二苯并二噁英(TCDD)是一系列有毒卤代芳香族化合物的原型,被认为会引起不利的生殖、免疫和代谢影响。对TCDD的许多生物反应是通过配体与芳香烃(Ah)受体结合来介导的,Ah受体也称为AhR。 Ah受体是一种配体依赖性转录因子,与特定的DNA序列相互作用,称为外源性应答元件(XRE),位于TCDD诱导基因的上游。在与配体结合后,Ah受体与Ah受体核转运子(Arnt)结合,复合物从细胞质转移到细胞核。 Arnt是Ah受体与XRE结合所必需的。 Ah受体和Arnt是转录因子家族的成员,包含一个基本螺旋-环-螺旋基序和一个常见的"PAS"基序。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Ah Receptor 抗体 (A-2) 参考文献:

  1. 类黄酮和白藜芦醇作为 Ah 受体活性的调节剂:防止二恶英中毒  |  Tutel'yan, VA., et al. 2003. Bull Exp Biol Med. 136: 533-9. PMID: 15500064
  2. 哺乳动物芳基烃(Ah)受体:从二恶英毒性的介质到皮肤和肝脏的生理功能。  |  Bock, KW. and Köhle, C. 2009. Biol Chem. 390: 1225-35. PMID: 19747074
  3. 芳香烃(Ah)受体 DNA 结合活性。序列特异性和 Zn2+ 需求。  |  Saatcioglu, F., et al. 1990. J Biol Chem. 265: 9251-8. PMID: 2160969
  4. Ah受体和Nrf2基因电池成员:醌类介导的氧化应激和内质网应激的调节因子。  |  Bock, KW. 2012. Biochem Pharmacol. 83: 833-8. PMID: 22192820
  5. Ah受体:机制研究与人类风险评估的相关性。  |  Cook, JC., et al. 1987. Environ Health Perspect. 76: 71-7. PMID: 2834195
  6. Ah受体与90-kDa热休克蛋白的关系。  |  Perdew, GH. 1988. J Biol Chem. 263: 13802-5. PMID: 2843537
  7. 异黄酮在结肠衍生细胞系中作为 Ah 受体激动剂: 结构-活性关系  |  Park, H., et al. 2019. Chem Res Toxicol. 32: 2353-2364. PMID: 31621310
  8. 人类单核细胞分化过程中Ah受体(TCDD受体)的表达。  |  Hayashi, S., et al. 1995. Carcinogenesis. 16: 1403-9. PMID: 7788861
  9. 小鼠胚胎腭中的Ah受体以及TCDD对受体表达的影响。  |  Abbott, BD., et al. 1994. Toxicol Appl Pharmacol. 126: 16-25. PMID: 8184424
  10. 吲哚羟基苯甲酸的Ah受体结合特性和肝雌二醇羟化诱导。  |  Jellinck, PH., et al. 1993. Biochem Pharmacol. 45: 1129-36. PMID: 8384853

订购信息

产品名称产品编号规格价格数量收藏夹

Ah Receptor 抗体 (A-2)

sc-398877
200 µg/ml
$322.00

Ah Receptor (A-2): m-IgG Fc BP-HRP 套装

sc-538534
200 µg Ab; 10 µg BP
$361.00

Ah Receptor (A-2): m-IgGκ BP-HRP 套装

sc-536165
200 µg Ab; 40 µg BP
$361.00

Ah Receptor (A-2): m-IgG1 BP-HRP 套装

sc-545752
200 µg Ab; 20 µg BP
$361.00

Ah Receptor (A-2) 中和勝肽

sc-398877 P
100 µg/0.5 ml
$69.00

Ah Receptor 抗体 (A-2) X

sc-398877 X
200 µg/0.1 ml
$322.00

Hi, I wanted to know if it is essential to perform Heart Induced Epitope Retrieval (HIER) when working with this antibody (sc-398877) for Immunoperoxidase staining. Thanks.

Asked by: Mashnia
Thank you for your question. Yes, we recommend antigen retrieval . Please see section C of our protocol for recommendations. https://www.scbt.com/resources/protocols/immunoperoxidase-staining
Answered by: BlakeJ
Date published: 2024-09-27

What application is the blocking peptide sc-398877 P appropriate for?

Asked by: Professor Griffin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by EKJP from Great antibody for WB and IHCThis antibody could detect AhR in several organs including the brain, liver and lung of wild-type C57BL/6J mice, but not AhR-null mice, in WB. This antibody also worked to identify AhR in brain neurons of wild-type mice, but not null mice, which indicates the specificity in IHC.
Date published: 2021-05-17
Rated 5 out of 5 by JM from Nice Western Blot data of Ah Receptor expressionNice Western Blot data of Ah Receptor expression in c4, NIH/3T3 and MCF7 whole cell lysates. -SCBT QC
Date published: 2014-11-25
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Ah Receptor 抗体 (A-2) is rated 5.0 out of 5 by 2.
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