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Nicotinic Acetylcholine Receptor delta/CHRND Antibody (C-4) - Western Blotting - Image 291015
AChRδ (C-4): sc-390896. SJRH30 (A) 和 BC3H1 (B) 全细胞裂解液中 AChRδ 表达的 Western 印迹分析.
AChRδ (C-4): sc-390896. SJRH30 (A) 和 BC3H1 (B) 全细胞裂解液中 AChRδ 表达的 Western 印迹分析.

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4): sc-390896

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寫評論提問

说明书
  • Nicotinic Acetylcholine Receptor delta/CHRND 抗体 C-4 是小鼠单克隆 IgG1 κ，Nicotinic Acetylcholine Receptor delta/CHRND抗体, 在2篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的AChRδ的C-terminus附近的氨基酸349-502之间
  • Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 AChRδ
  • 抗Nicotinic Acetylcholine Receptor delta/CHRND抗体（C-4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Nicotinic Acetylcholine Receptor delta/CHRND (C-4): sc-390896的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG1 BP-HRP 是 Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 AChR 抗体 包括 AChR α, AChR α 1, AChR α 2, AChR α 3, AChR α 4, AChR α 5, AChR α 6, AChR α 7, AChR α 8和AChR α 9

AChRδ抗体（C-4）是一种IgG1 κ小鼠单克隆AChR δ抗体（也称为CHRND抗体，或ACHRD抗体，烟碱乙酰胆碱受体δ抗体），可通过WB、IP、IF、IHC（P）和ELISA检测小鼠、大鼠和人的AChR δ蛋白。AChRδ抗体（C-4）既可作为非偶联抗AChR δ抗体形式，也可作为多种偶联形式的抗AChR δ抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。配体门控离子通道受体家族的成员以对神经递质的快速传递反应为特征。该家族的两个重要成员是烟碱乙酰胆碱受体和谷氨酸受体，两者均由五个同源亚基组成，形成跨膜水孔。这些跨膜受体在响应其同源神经递质时会改变构象。烟碱乙酰胆碱受体（AChRs）存在于神经肌肉接头的突触后膜上，与乙酰胆碱分子结合，使离子通过孔道移动。谷氨酸受体存在于中枢神经系统细胞的突触后膜上。乙酰胆碱结合在突触处产生的活性被乙酰胆碱酯酶终止，这是一种快速水解乙酰胆碱的酶。AChRδ，也称为CMS2A、FCCMS、SCCMS或CHRND，是一种由517个氨基酸组成的多通道膜蛋白，与致死型多发性翼状胬肉综合征、先天性肌无力综合征慢通道型（SCCMS）和先天性肌无力综合征快通道型（FCCMS）有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) 参考文献:

  1. 利用傅立叶变换红外差分光谱探测尼古丁乙酰胆碱受体的构象变化。  |  Baenziger, JE., et al. 1992. Biophys J. 62: 64-6. PMID: 1600101
  2. 大脑中的配体门控离子通道：氨基酸受体超家族。  |  Betz, H. 1990. Neuron. 5: 383-92. PMID: 1698394
  3. 乙酰胆碱酯酶再激活剂改变了尼古丁乙酰胆碱受体离子通道的功能特性。  |  Alkondon, M., et al. 1988. J Pharmacol Exp Ther. 245: 543-56. PMID: 2452874
  4. 神经递质的作用：打开配体门控离子通道。  |  Unwin, N. 1993. Cell. 72 Suppl: 31-41. PMID: 7679054
  5. 神经元烟碱乙酰胆碱受体的多样性。  |  Sargent, PB. 1993. Annu Rev Neurosci. 16: 403-43. PMID: 7681637
  6. 神经递质的定量释放和长期电位。  |  Stevens, CF. 1993. Cell. 72 Suppl: 55-63. PMID: 8094037
  7. NMDA 受体在信息处理中的作用。  |  Daw, NW., et al. 1993. Annu Rev Neurosci. 16: 207-22. PMID: 8460891
  8. α5亚基对神经元乙酰胆碱受体通道的功能贡献。  |  Ramirez-Latorre, J., et al. 1996. Nature. 380: 347-51. PMID: 8598930

订购信息

产品名称产品编号规格价格数量收藏夹

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4)

sc-390896
200 µg/ml
$316.00

Nicotinic Acetylcholine Receptor delta/CHRND (C-4): m-IgG1 BP-HRP 套装

sc-551588
200 µg Ab; 20 µg BP
$354.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) AC

sc-390896 AC
500 µg/ml, 25% agarose
$416.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) HRP

sc-390896 HRP
200 µg/ml
$316.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) FITC

sc-390896 FITC
200 µg/ml
$330.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) PE

sc-390896 PE
200 µg/ml
$343.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) Alexa Fluor® 488

sc-390896 AF488
200 µg/ml
$357.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) Alexa Fluor® 546

sc-390896 AF546
200 µg/ml
$357.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) Alexa Fluor® 594

sc-390896 AF594
200 µg/ml
$357.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) Alexa Fluor® 647

sc-390896 AF647
200 µg/ml
$357.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) Alexa Fluor® 680

sc-390896 AF680
200 µg/ml
$357.00

Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) Alexa Fluor® 790

sc-390896 AF790
200 µg/ml
$357.00

Nicotinic Acetylcholine Receptor delta/CHRND (C-4) 中和勝肽

sc-390896 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-390896 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-04-06

Regarding: AChRδ Antibody (C-4): sc-390896 Is this antibody purified? Is it possible to obtain this antibody in larger amounts and higher concentrations (e.g. 1-5 mg/ml)? Thanks

Asked by: BD17
Thank you for your question. Yes, this mouse monoclonal antibody is purified. Please contact one of our Special Orders Coordinators to request a quote for a larger quantity and discuss your preferred specifications and format for the antibody. Please call us toll-free at (800) 457-3801 option 2, or email specialorders@scbt.com.
Answered by: Technical Support
Date published: 2017-02-18
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Rated 5 out of 5 by from Great antibody!This antibody is perfect for western blotting. I could detect AChRδ from C2C12 cells.
Date published: 2017-04-06
Rated 5 out of 5 by from works very well for western blottingIn western blotting this antibody specifically recognised a lysate extract from HEK293T cells transfected with human cDNA encoding the AChR delta subunit. A lysate from mock transfected HEK293T cells was not recognised at all. The antibody was diluted 1:100 and the secondary 1:500 but the primary could be diluted a lot more than this (autoradiograph exposed for about 1 second!)
Date published: 2016-12-15
Rated 5 out of 5 by from Produced positive Western blot data of AChRProduced positive Western blot data of AChR expression in SJRH30 and BC3H1 whole cell lysates. -SCBT QC
Date published: 2013-01-21
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Nicotinic Acetylcholine Receptor delta/CHRND 抗体 (C-4) is rated 5.0 out of 5 by 3.
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