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ABCG2 Antibody (BXP-21) - Western Blotting - Image 15561
ABCG2 抗体 (BXP-21): sc-58222. HL-60/MX-1 (A) 和 JAR (B) 全细胞裂解液中 ABCG2 表达的 Western 印迹分析.
ABCG2 Antibody (BXP-21) - Western Blotting - Image 15561
ABCG2 抗体 (BXP-21): sc-58222. HL-60/MX-1 (A) 和 JAR (B) 全细胞裂解液中 ABCG2 表达的 Western 印迹分析.
ABCG2 Antibody (BXP-21) - Immunofluorescence - Image 145138
ABCG2 抗体 (BXP-21): sc-58222. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示膜定位.
ABCG2 Antibody (BXP-21) - Western Blotting - Image 65897
ABCG2 抗体 (BXP-21): sc-58222. 非转染: sc-117752 (A) 和人 ABCG2 转染: sc-172393 (B) 293T 全细胞裂解液中 ABCG2 表达的 Western 印迹分析.
ABCG2 抗体 (BXP-21): sc-58222. HL-60/MX-1 (A) 和 JAR (B) 全细胞裂解液中 ABCG2 表达的 Western 印迹分析.

ABCG2 抗体 (BXP-21): sc-58222

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寫評論提問

说明书
  • ABCG2 抗体 BXP-21 是小鼠单克隆 IgG2a, 在121篇文献中引用，提供 100 µg/ml
  • 免疫human物种的ABCG2的氨基酸271-396
  • 推荐用于 mouse, rat 和 human 来源的ABCG2 WB, IP, IF 和 IHC(P)检测; 与human MDR1, MRP1 and MRP2 gene products不交叉反应
  • 看 ABCG2 (B-1): sc-377176，可查看有标记的 ABCG2 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成ABCG2 抗体 (BXP-21)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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研究信息

関連項目

此外 ABC 抗体 包括 ABCF1, ABCG2, ABCF2, ABCA6, ABCB9, ABCC13, ABCC11, ABCD3和ABCB5

ABCG2抗体（BXP-21）是一种IgG2a小鼠单克隆ABCG2抗体（也称为CD338抗体），可通过WB、IP、IF和IHC检测小鼠、大鼠和人类来源的ABCG2（P）。ABCG2抗体（BXP-21）可作为非偶联的抗ABCG2抗体形式提供。ATP结合盒（ABC）转运蛋白是一个进化保守的蛋白质家族，通过ATP水解的能量催化分子跨细胞外和细胞内膜的运输。ABC半转运蛋白ABCG2也被称为胎盘特异性ABC转运蛋白和乳腺癌症耐药性蛋白（BCRP1）。ABCG2对多种化疗药物具有抗性，包括蒽环类、米托蒽醌、比沙替尼和拓扑替康。在正常情况下，ABCG2可以通过清除细胞中的毒素发挥保护作用，并在调节干细胞分化中发挥重要作用。ABCG2负责侧群（SP）表型，并在多种干细胞中广泛表达，使其成为重要的干细胞标记。ABCG2可能具有N-连接的糖基化，并可能在体内二聚化。ABCG2在胎盘、肝脏、肠和干细胞中大量表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ABCG2 抗体 (BXP-21) 参考文献:

  1. 通过流式细胞仪鉴定神经球细胞表型。  |  Hulspas, R. and Quesenberry, PJ. 2000. Cytometry. 40: 245-50. PMID: 10878568
  2. ABC转运体是干细胞的表型标记和功能调节器。  |  Bunting, KD. 2002. Stem Cells. 20: 11-20. PMID: 11796918
  3. 小鼠侧群干细胞的正常数量需要 Bcrp1 基因的表达，Bcrp1 基因的表达可使体内造血细胞对米托蒽醌产生相对保护作用。  |  Zhou, S., et al. 2002. Proc Natl Acad Sci U S A. 99: 12339-44. PMID: 12218177
  4. 多药耐药性与癌症：人类 ABC 转运体 ABCG2 的作用。  |  Ejendal, KF. and Hrycyna, CA. 2002. Curr Protein Pept Sci. 3: 503-11. PMID: 12369998
  5. 人类 ABCG2 多药转运体的药物转运, ATP 水解和核苷酸捕获特征。通过点突变改变底物特异性。  |  Ozvegy, C., et al. 2002. J Biol Chem. 277: 47980-90. PMID: 12374800
  6. ABCG2通过ATP依赖性转运产生对吲哚咔唑化合物的抗性。  |  Nakagawa, R., et al. 2002. Biochem Biophys Res Commun. 299: 669-75. PMID: 12459192
  7. 人类胃肠道癌细胞的特征。  |  Haraguchi, N., et al. 2006. Stem Cells. 24: 506-13. PMID: 16239320
  8. 小鼠多能造血干细胞的静止和活化亚群。  |  Spangrude, GJ. and Johnson, GR. 1990. Proc Natl Acad Sci U S A. 87: 7433-7. PMID: 1977160
  9. 丹参酮 I 是一种新型 EZH2 抑制剂，可通过上调 MMP9 和 ABCG2 限制正常和恶性造血。  |  Huang, Y., et al. 2021. Theranostics. 11: 6891-6904. PMID: 34093860
  10. ABCG2是一种抑制抗菌先天免疫的伊托酸转运蛋白，它通过减轻TFEB依赖性溶酶体生物发生来发挥作用。  |  Chen, C., et al. 2024. Cell Metab. 36: 498-510.e11. PMID: 38181789
  11. 表达ABCG2的克隆再填充内皮细胞有助于形成和维持血管。  |  Lin, Y., et al. 2024. Circulation. 150: 451-465. PMID: 38682338
  12. 染料外流研究表明，在多个物种中都存在表达低水平或检测不到水平 CD34 抗原的造血干细胞。  |  Goodell, MA., et al. 1997. Nat Med. 3: 1337-45. PMID: 9396603

订购信息

产品名称产品编号规格价格数量收藏夹

ABCG2 抗体 (BXP-21)

sc-58222
100 µg/ml
$316.00

For this antibody, when we do Facs, is it intracellular?

Asked by: Iamjc819
Thank you for your question. The protein this antibody recognises is present in plasma membrane and mitochondria. The antibody's epitope region spans amino acids 271-396, which corresponds to a cytoplasmic, i.e. intracellular, domain.
Answered by: Tech Support Europe
Date published: 2022-03-29

Hi, I am looking for the concentration of the antibody sc-58222. Could you provide it please? Thank you

Asked by: Anonymous
Thank you for your question. Each vial of this antibody contains 500 µl culture supernatant containing IgG2a with < 0.1% sodium azide and 0.7% stabilizer protein. We do not provide a concentration as it is a supernatant antibody.
Answered by: Tech Service
Date published: 2020-02-19

Is this antibody cross-reactive with MDR1 or any other gene products?

Asked by: AbPolly
Thank you for your inquiry. This ABCG2 antibody is non cross-reactive with the human MDR1, MRP1 and MRP2 gene products. Please contact Technical Service for information and alignments with any other proteins.
Answered by: Technical Service
Date published: 2016-12-22
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Rated 4 out of 5 by from SIRTs inhibitors and sorafenibCambinol and EX-527 affect the expression of some ABC transporters during sorafenib treatment
Date published: 2021-02-26
Rated 5 out of 5 by from Reliable and robust productIt worked for inmunoblotting with a strong signal at a dilution 1:800 for mice and rat tissues(gut and liver). I strongly recommend the product
Date published: 2019-12-04
Rated 4 out of 5 by from Good features!I hope that this antibody is good for my ABCG2 variant expression!
Date published: 2019-05-27
Rated 5 out of 5 by from Comparative trialsWe know that ABCG2 can play a protective role by removing toxins from cells and play an important role in regulating stem cell differentiation. We use it to be widely expressed in a large number of stem cells, making it an important stem cell marker for comparative trials.
Date published: 2017-02-11
Rated 5 out of 5 by from Great monoclonal antibodyExcellent monoclonal antibody for detecting endogenous ABCG2 by Western blot and IF. Cited in over 30 publications! Highly recommended
Date published: 2016-12-19
Rated 3 out of 5 by from OK for Western blot analysisOK for Western blot analysis, suitable for immunofluorescence analysis
Date published: 2015-10-12
Rated 5 out of 5 by from Good specificity shown by using transfectedGood specificity shown by using transfected and non-transfected 293T cells for over-expression of the human ABCG2 protein via Western Blot analysis. -SCBT QC
Date published: 2015-05-02
Rated 5 out of 5 by from Publishable immunostaining in paraformaldehydePublishable immunostaining in paraformaldehyde fixed rat brain tissue. -SCBT Publication Review
Date published: 2015-04-28
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ABCG2 抗体 (BXP-21) is rated 4.6 out of 5 by 14.
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