AAF-CMK (CAS 184901-82-4)

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备用名: Tripeptidyl Peptidase Inhibitor

应用； AAF-CMK is a serine protease inhibitor that inhibits tripeptidyl peptidase II (TPPII)

CAS号码: 184901-82-4

纯度: ≥95%

分子量: 453.9

分子式: C₁₆H₂₂ClN₃O₃•C₂HF₃O₂

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions1, and reversibly inhibits Cln2 (TPPI). AAF-CMK shows only marginal inhibition of the chymotrypsin-like activity of the proteasome.

参考文献

1. Vines, D., 1998. Purification and characterisation of a tripeptidyl aminopeptidase I from rat spleen. Biochimica et biophysica acta. 1384(2): 233-42. PMID: 9659384
2. Geier, E., 1999. A giant protease with potential to substitute for some functions of the proteasome. Science (New York, N.Y.). 283(5404): 978-81. PMID: 9974389

物理状态 :

Solid

顺序 :

Ala-Ala-Phe-CMK

溶解度 :

Soluble in water.

保存 :

Store at -20° C

Ki 数据 :

tripeptidyl peptidase I: K_i= 63 nM

仅供科研使用。不可用于诊断或治疗。

PubChem CID :

71433962

SMILES :

C[[email protected]@H](C(=O)NC(=O)[[email protected]](C)N[[email protected]@H](CC1=CC=CC=C1)C(=O)CCl)N.C(=O)(C(F)(F)F)O

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