AAF-CMK CAS: 184901-82-4
MF: C16H22ClN3O3•C2HF3O2
MW: 453.9
A serine protease inhibitor that inhibits tripeptidyl peptidase II (TPPII).

AAF-CMK (CAS 184901-82-4)

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备用名: Tripeptidyl Peptidase Inhibitor
应用; AAF-CMK is a serine protease inhibitor that inhibits tripeptidyl peptidase II (TPPII)
CAS号码: 184901-82-4
纯度: ≥95%
分子量: 453.9
分子式: C16H22ClN3O3•C2HF3O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions1, and reversibly inhibits Cln2 (TPPI). AAF-CMK shows only marginal inhibition of the chymotrypsin-like activity of the proteasome.


参考文献

1. Vines, D., 1998. Purification and characterisation of a tripeptidyl aminopeptidase I from rat spleen. Biochimica et biophysica acta. 1384(2): 233-42. PMID: 9659384
2. Geier, E., 1999. A giant protease with potential to substitute for some functions of the proteasome. Science (New York, N.Y.). 283(5404): 978-81. PMID: 9974389

物理状态 :
Solid
顺序 :
Ala-Ala-Phe-CMK
溶解度 :
Soluble in water.
保存 :
Store at -20° C
Ki 数据 :
tripeptidyl peptidase I: Ki= 63 nM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
C[[email protected]@H](C(=O)NC(=O)[[email protected]](C)N[[email protected]@H](CC1=CC=CC=C1)C(=O)CCl)N.C(=O)(C(F)(F)F)O

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PMID: # 21342435  Dabrazhynetskaya, A. et al. 2011. J Cell Mol Med. 16: -.

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