7Z,10Z,13Z,16Z,19Z-Docosapentaenoic acid CAS: 24880-45-3
MF: C22H34O2
MW: 330.50
A fatty acid shown to inhibit platelet aggregation.

7Z,10Z,13Z,16Z,19Z-Docosapentaenoic acid (CAS 24880-45-3)

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同义词: Docosapentaenoic acid
应用; A fatty acid shown to inhibit platelet aggregation
CAS号码: 24880-45-3
纯度: ≥98%
分子量: 330.50
分子式: C22H34O2
* 参考分析证明 大量特定数据 (包括水 含量).
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Docosa-7Z,10Z,13Z,16Z,19Z-pentaenoic Acid (22:5, n-3), also known as DPA, is a fatty acid derived from fish oils that potently inhibits platelet aggregation. DPA has been reported to block the cyclooxygenase pathway and stimulate the lipoxygenase pathway, which results in effective platelet aggregation inhibition. Peripheral blood mononuclear cell research demonstrates that DPA diminishes cyclooxygenase-2 levels intracellularly and inhibits pro-inflammatory prostaglandin E2 production. Studies indicate that the compound plays an important role in the cubic membrane formation of mitochondria found in amoeba Chaos.


参考文献

1. Akiba, S., et al. 2000. Biol. Pharm. Bull. 23: 1293-1297. PMID: 11085354
2. Rissanen, T., et al. 2000. Circulation. 102: 2677-2679. PMID: 11094031
3. Deng, Y., et al. 2009. FASEB J. 23: 2866-2871. PMID: 19406841
4. Nauroth, J.M., et al. 2010. Lipids. 45: 375-384. PMID: 20364438
5. Kaur, G., et al. 2011. Prog. Lipid Res. 50: 28-34. PMID: 20655949

外观 :
Oil
物理状态 :
Liquid
溶解度 :
Soluble in ethanol, hexane, methylene chloride, 0.1M Na2CO3 (1.7 mg/ml), water (1.7 mg/ml) at 25° C, DMSO (~100 mg/ml), and DMF (~100 mg/ml).
保存 :
Store at -20° C
折射率 :
n20D 1.51
IC50 :
Cytochrome P450 19A1: IC50 = 16.8 µM (human)
pK值 :
pKa: 4.76
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
2
RTECS :
JR1320000
PubChem CID :
5497182
MDL 号码 :
MFCD00156103
SMILES :
CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCCCC(=O)O

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