7-Hydroxyaristolochic acid A CAS: 79185-75-4
MF: C17H11NO8
MW: 357.27
An aristolochic acid associated with urothelial carcinoma formation.

7-Hydroxyaristolochic acid A (CAS 79185-75-4)

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备用名: 6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
应用; 7-Hydroxyaristolochic acid A is an aristolochic acid associated with urothelial carcinoma formation
CAS号码: 79185-75-4
分子量: 357.27
分子式: C17H11NO8
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

7-Hydroxyaristolochic acid A is an aristolochic acid. These compounds are the active ingredients, responsible for the hepatoxicity and renal toxicity, found in Aristolochic fangchi. They form DNA adducts in renal tissue and are associated with urothelial carcinoma formation.


参考文献

1. Pfau, W., et al., 1990. 32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II. Carcinogenesis. 11(9): 1627-33. PMID: 2401053
2. Rossiello, M R., et al., 1993. Induction of hepatic nodules in the rat by aristolochic acid. Cancer letters. 71(1-3): 83-7. PMID: 8364902
3. Mengs, U., et al., 1993. Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology. Archives of toxicology. 67(5): 307-11. PMID: 8368940
4. Hadjiolov, D., et al., 1993. Effect of diallyl sulfide on aristolochic acid-induced forestomach carcinogenesis in rats. Carcinogenesis. 14(3): 407-10. PMID: 8453716
5. Schmeiser, H H., et al., 1996. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer research. 56(9): 2025-8. PMID: 8616845
6. Levi, M., et al., 1998. Acute hepatitis in a patient using a Chinese herbal tea--a case report. Pharmacy world & science : PWS. 20(1): 43-4. PMID: 9536471
7. Nortier, J L., et al., 2000. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi) The New England journal of medicine. 342(23): 1686-92. PMID: 10841870

物理状态 :
Solid
溶解度 :
Soluble in water.
保存 :
Store at -20° C
熔点 :
287-292° C
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
COC1=C(C=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O)O

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