Molecular structure of (2R,4R)-APDC, CAS Number: 169209-63-6
(2R,4R)-APDC (CAS 169209-63-6)
See product citations (2)
Application:
(2R,4R)-APDC is a highly selective agonist for group II metabotropic glutamate receptors (mGluR)
CAS Number:
169209-63-6
Purity:
>98%
Molecular Weight:
174.16
Molecular Formula:
C6H10N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(2R,4R)-APDC, an organic molecule, finds extensive application in various scientific research endeavors. This chiral compound possesses two asymmetric carbon atoms and is renowned for its versatile synthesis methods. The biological and biochemical effects of (2R,4R)-APDC have been widely investigated. While the complete mechanism of action of (2R,4R)-APDC remains elusive, it is postulated that this compound acts as an inhibitor of the enzyme dihydrofolate reductase (DHFR). This enzyme plays a vital role in folate biosynthesis. The inhibition of (2R,4R)-APDC may result in the suppression of cell proliferation and the induction of apoptosis.
(2R,4R)-APDC (CAS 169209-63-6) References
- Effect of the group II metabotropic glutamate agonist, 2R,4R-APDC, varies with age, layer, and visual experience in the visual cortex. | Beaver, CJ., et al. 1999. J Neurophysiol. 82: 86-93. PMID: 10400937
- Pharmacological agents acting at subtypes of metabotropic glutamate receptors. | Schoepp, DD., et al. 1999. Neuropharmacology. 38: 1431-76. PMID: 10530808
- The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice. | Moldrich, RX., et al. 2001. Neurosci Lett. 299: 125-9. PMID: 11166954
- 2R,4R-APDC influence on hypoxia-induced impairment of learning and memory processes in passive avoidance test. | Car, H., et al. 2004. Pol J Pharmacol. 56: 527-37. PMID: 15591640
- 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. | Yao, H., et al. 2007. Neuroreport. 18: 1459-62. PMID: 17712274
- Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. | Gross, O., et al. 2009. Nature. 459: 433-6. PMID: 19339971
- Effects of the group II mGlu receptor agonist 2R,4R-APDC on dentate gyrus cell proliferation in the adult rat brain after diffuse brain injury. | Feng, YB., et al. 2011. Neurol Res. 33: 381-8. PMID: 21535937
- Inhibitory effect of group II mGluR agonist 2R, 4R-APDC on cell proliferation in dentate gyrus in rats with epileptic seizure. | Yao, H., et al. 2015. Eur Rev Med Pharmacol Sci. 19: 2922-7. PMID: 26241549
- Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4- dicarboxylate. | Schoepp, DD., et al. 1995. Neuropharmacology. 34: 843-50. PMID: 8532165
- Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. | Monn, JA., et al. 1996. J Med Chem. 39: 2990-3000. PMID: 8709133
- Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists. | Mistry, R., et al. 1998. Br J Pharmacol. 123: 581-9. PMID: 9504400
- Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats. | Attwell, PJ., et al. 1998. Brain Res. 787: 286-91. PMID: 9518652
- Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death. | Battaglia, G., et al. 1998. Eur J Pharmacol. 356: 271-4. PMID: 9774259
Activator of:
mGluR-2, and mGluR-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(2R,4R)-APDC, 1 mg | sc-202408 | 1 mg | $84.00 | |||
(2R,4R)-APDC, 5 mg | sc-202408A | 5 mg | $393.00 |