13(S)-HOTrE (CAS 87984-82-5)

13(S)-HOTrE, cataloged under CAS number 87984-82-5, is the S-enantiomer of 13-hydroxyoctadecatrienoic acid, a biologically active hydroxylated derivative of linolenic acid. This compound is primarily formed through the action of lipoxygenase enzymes, which oxygenate polyunsaturated fatty acids, leading to the generation of various hydroxylated fatty acids with signaling capabilities within cellular environments. 13(S)-HOTrE serves as a crucial molecule in the study of lipid-mediated cellular signaling mechanisms, particularly in the context of inflammation and oxidative stress responses. Its mechanism of action involves modulating the activity of key signaling pathways, including those linked to the regulation of gene expression and the inflammatory cascade. By binding to specific receptors, such as peroxisome proliferator-activated receptors (PPARs), 13(S)-HOTrE influences transcriptional activities that govern cellular responses to environmental and metabolic stimuli. In research, this compound is utilized to explore its role in cellular defense mechanisms against oxidative damage and to understand its contribution to maintaining cellular homeostasis under stress conditions. The insights gained from studies involving 13(S)-HOTrE enhance our understanding of the complex network of lipid signaling that affects cell function and adaptation, providing a deeper knowledge of how cells regulate responses to physiological challenges through lipid-derived mediators.