Date published: 2025-10-10

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VWC2激活剂

The chemical class known as VWC2 Activators encompasses a range of compounds that can exert influence on the von Willebrand factor type C domain-containing protein 2 (VWC2) through indirect mechanisms involving various cellular signaling pathways and processes. These activators can modulate the activity of VWC2 not by binding directly to it, but by altering the cellular environment or the signaling cascades that VWC2 is a part of. The chemicals that fall under this category are often inhibitors or agonists of pathways such as BMP signaling, TGF-β signaling, integrin-mediated cell adhesion, and collagen synthesis. By intervening in these pathways, VWC2 activators can alter the downstream effects that ultimately affect the function of VWC2 within the cell.

The action of VWC2 activators is typically characterized by their ability to influence cellular processes that are either directly or indirectly related to the role of VWC2. This can include modulation of extracellular matrix organization, angiogenesis, and cell survival pathways. The changes induced by these chemicals can result in an alteration of the normal functioning of VWC2, which in turn can lead to changes in the cellular processes that VWC2 influences. It is through these nuanced and interconnected pathways that these activators can exert their effects, often involving a cascade of intracellular events that lead to the modulation of VWC2's activity. As such, the term VWC2 Activators is used to denote a broad and diverse set of compounds that share the common feature of being able to engage with and influence the function of VWC2 through indirect yet significant means within the cellular milieu.

関連項目

产品名称CAS #产品编号数量价格应用排名

BML-275

866405-64-3sc-200689
sc-200689A
5 mg
25 mg
$94.00
$348.00
69
(1)

多索吗啡可抑制 BMP 信号传导,并可能通过改变 VWC2 与之相互作用的途径来激活 VWC2。

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

1062368-24-4sc-476297
5 mg
$240.00
(0)

LDN-193189 是一种选择性 BMP 信号抑制剂,可能通过调节参与 BMP 通路的蛋白质的活性来激活 VWC2。

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$80.00
$212.00
$408.00
48
(1)

SB-431542 可抑制 TGF-β 通路,这可能会通过影响 BMP 通路和与该信号相关的 VWC2 等蛋白来激活 VWC2。

Thiazovivin

1226056-71-8sc-361380
sc-361380A
10 mg
25 mg
$278.00
$622.00
15
(1)

噻唑维文是一种 ROCK 抑制剂,可促进细胞粘附和存活,并可能通过影响细胞相互作用和 ECM 组成来激活 VWC2。

A 83-01

909910-43-6sc-203791
sc-203791A
10 mg
50 mg
$198.00
$650.00
16
(1)

A-83-01 可抑制 TGF-β I 型受体 ALK5,从而可能通过改变 TGF-β/BMP 相关途径激活 VWC2。

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$182.00
$693.00
88
(1)

Y-27632 是一种 ROCK 抑制剂,可影响细胞骨架动力学和细胞形状,并可能通过影响其功能的细胞环境来激活 VWC2。

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

蕨麻素能提高 cAMP 水平,从而激活 PKA,并可能通过影响相关途径激活 VWC2。

Puerarin

3681-99-0sc-202301
sc-202301A
5 mg
100 mg
$129.00
$205.00
1
(0)

研究表明,葛根素能刺激 BMP 通路并促进成骨细胞分化,这可能会影响 VWC2 在该通路中的功能,从而激活 VWC2。

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

染料木素是一种酪氨酸激酶抑制剂,有可能通过调节各种信号通路(包括可能与 VWC2 功能交叉的信号通路)来激活 VWC2。