Date published: 2026-7-26

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INSIG Antibodies

Santa Cruz Biotechnology features a diverse variety of INSIG monoclonal antibodies for advanced research in cellular and molecular biology. INSIG monoclonal antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). INSIG proteins play a crucial role in regulating cholesterol homeostasis and lipid metabolism by interacting with sterol regulatory element-binding proteins (SREBPs). INSIG proteins maintain cellular lipid levels and prevent excessive cholesterol accumulation, which is vital for cellular health and function. Understanding INSIG protein mechanisms can provide insights into metabolic disorders and potential therapeutic targets. Researchers studying lipid metabolism can utilize INSIG monoclonal antibodies to examine protein expression patterns and cellular localization. INSIG monoclonal antibodies enable detailed investigation of protein-protein interactions and regulatory pathways involved in cholesterol metabolism. Santa Cruz Biotechnology monoclonal antibodies for INSIG research support scientists worldwide in advancing our understanding of metabolic regulation and disease mechanisms.

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INSIG Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

INSIG-1 Antibody (A-9)

sc-390504mouse IgG1 κ31-100 (h)WB, IP, IF, IHC(P), ELISAm, r, h
10
(5)

INSIG siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

INSIG-1 siRNA (h)

sc-44432hGene SilencingN/A
4
(0)

INSIG-1 shRNA Plasmid (h)

sc-44432-SHhGene SilencingPuromycin
4
(0)

INSIG-1 shRNA (h) Lentiviral Particles

sc-44432-VhGene SilencingPuromycin
4
(0)

INSIG-1 siRNA (m)

sc-44433mGene SilencingN/A0
(0)

INSIG-1 shRNA Plasmid (m)

sc-44433-SHmGene SilencingPuromycin0
(0)

INSIG-1 shRNA (m) Lentiviral Particles

sc-44433-VmGene SilencingPuromycin0
(0)

INSIG-1 siRNA (r)

sc-270655rGene SilencingN/A0
(0)

INSIG-1 shRNA Plasmid (r)

sc-270655-SHrGene SilencingN/A0
(0)

INSIG-1 shRNA (r) Lentiviral Particles

sc-270655-VrGene SilencingN/A0
(0)

INSIG-2 siRNA (h)

sc-45781hGene SilencingN/A
3
(0)

INSIG-2 shRNA Plasmid (h)

sc-45781-SHhGene SilencingPuromycin
3
(0)

INSIG-2 shRNA (h) Lentiviral Particles

sc-45781-VhGene SilencingPuromycin
3
(0)

INSIG-2 siRNA (m)

sc-45782mGene SilencingN/A0
(0)

INSIG-2 shRNA Plasmid (m)

sc-45782-SHmGene SilencingPuromycin0
(0)

INSIG-2 shRNA (m) Lentiviral Particles

sc-45782-VmGene SilencingPuromycin0
(0)

INSIG CRISPR Knockout (KO) and HDR Plasmids

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INSIG-1 CRISPR/Cas9 KO Plasmid (h)

sc-401381Gene Knockouth0
(0)

INSIG-1 HDR Plasmid (h)

sc-401381-HDRHomology Directed Repairh0
(0)

INSIG-1 CRISPR/Cas9 KO Plasmid (m)

sc-433033Gene Knockoutm0
(0)

INSIG-1 HDR Plasmid (m)

sc-433033-HDRHomology Directed Repairm0
(0)

INSIG-2 CRISPR/Cas9 KO Plasmid (h)

sc-402255Gene Knockouth0
(0)

INSIG-2 HDR Plasmid (h)

sc-402255-HDRHomology Directed Repairh0
(0)

INSIG-2 CRISPR/Cas9 KO Plasmid (m)

sc-428482Gene Knockoutm0
(0)

INSIG-2 HDR Plasmid (m)

sc-428482-HDRHomology Directed Repairm0
(0)

INSIG CRISPR Double Nickase Plasmids

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INSIG-1 Double Nickase Plasmid (h)

sc-401381-NICGene Knockouth0
(0)

INSIG-1 Double Nickase Plasmid (h2)

sc-401381-NIC-2Gene Knockouth0
(0)

INSIG-2 Double Nickase Plasmid (h)

sc-402255-NICGene Knockouth0
(0)

INSIG-2 Double Nickase Plasmid (h2)

sc-402255-NIC-2Gene Knockouth0
(0)

INSIG CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

INSIG-1 CRISPR Activation Plasmid (h)

sc-401381-ACTGene Activationh0
(0)

INSIG-1 CRISPR Activation Plasmid (h2)

sc-401381-ACT-2Gene Activationh0
(0)

INSIG-2 CRISPR Activation Plasmid (h)

sc-402255-ACTGene Activationh0
(0)

INSIG-2 CRISPR Activation Plasmid (h2)

sc-402255-ACT-2Gene Activationh0
(0)