The chemical class of Erich2 Activators comprises a diverse range of compounds postulated to modulate the activity of Erich2, a protein whose detailed functions and interactions within cellular pathways are not extensively documented. This class includes various molecules, each possessing unique properties and mechanisms to potentially engage and activate pathways associated with Erich2. From agents that increase intracellular signaling messengers like cAMP (e.g., Forskolin) to those that modulate specific receptor pathways (e.g., Epidermal Growth Factor (EGF)), the scope of these activators is broad. Other members of this class, such as Ionomycin, work by altering ion concentrations, specifically calcium, thereby influencing a range of calcium-dependent cellular processes. This variety highlights the multifaceted approach these compounds might employ to exert their influence on Erich2 activity. The activators are not limited to a single mode of action but rather represent a spectrum of interactions, including the activation of kinase pathways (e.g., Phorbol 12-myristate 13-acetate (PMA) with PKC), modification of growth factor signaling (e.g., Insulin-like Growth Factor-1 (IGF-1)), and modulation of hormone-driven pathways (e.g., Estradiol and Dehydroepiandrosterone (DHEA)).
The significance of the Erich2 Activators class lies in its potential to offer insights into the regulation and function of Erich2 within the cell. These activators, through their varied actions, provide a toolset to probe the biological roles of Erich2. They can shed light on the signaling pathways that Erich2 might be a part of, as well as its possible involvement in critical cellular functions. For instance, compounds like FGF-basic and Sphingosine-1-phosphate (S1P) underscore the potential involvement of Erich2 in processes like cell growth, differentiation, and response to external signaling molecules. Additionally, the inclusion of compounds like Nicotinamide mononucleotide (NMN), which influences NAD+ biosynthesis, opens avenues to explore Erich2's role in metabolic pathways. Collectively, this class of activators is not just a group of chemicals with a shared target but represents a key to understanding the complex network of cellular signaling and regulation. Their study and application could illuminate the intricate dance of molecular interactions and pathways within the cell, offering a deeper understanding of how proteins like Erich2 contribute to the orchestration of cellular life.
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产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA激活蛋白激酶C(PKC),后者可以磷酸化一系列蛋白质,包括ERICH2。鉴于PKC作用于广泛的细胞蛋白,可以推断当ERICH2被PMA激活时,它可能是PKC的潜在底物。 | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
佛司可林可提高细胞内cAMP水平,从而激活蛋白激酶A(PKA)。PKA可以磷酸化多种蛋白质。ERICH2是一种细胞蛋白,可以被PKA磷酸化并激活,作为信号通路的一部分。 | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
异诺霉素是一种钙离子诱导剂,可增加细胞内钙含量,从而激活钙/钙调蛋白依赖性蛋白激酶(CaMK)。这些激酶可以磷酸化和激活多种蛋白质,ERICH2 可能会被激活,这是细胞内钙升高的下游效应的一部分。 | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
冈田酸是蛋白磷酸酶1和2A的强效抑制剂,由于去磷酸化减少,导致多种蛋白的磷酸化水平增加。ERICH2可能会因这些磷酸酶的活性降低而保持激活状态 | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
已知安乃近能激活应激活化蛋白激酶(SAPKs),如 JNK。这些激酶可使多种细胞蛋白磷酸化。如果ERICH2是JNK或相关激酶的靶标,那么它的活化可能是异霉素作用于这些信号分子的结果。 | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin 通过抑制肌浆/内质网 Ca2+ ATP 酶(SERCA)破坏钙平衡,导致细胞膜钙水平升高。这会导致许多依赖钙的酶和信号通路被激活,其中可能包括激活 ERICH2 的酶和信号通路。 | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
过氧化氢可作为一种氧化剂,已被证明会影响各种信号转导途径,尤其是涉及氧化应激反应的途径。它可以导致一系列激酶的激活,这些激酶可以磷酸化和激活 ERICH2,作为其信号作用的一部分。 | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
醋酸锌提供的锌离子可作为许多蛋白质的重要辅助因子,如果ERICH2的功能需要锌,它可能会直接促进ERICH2的催化活性。 | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $45.00 $68.00 $160.00 $240.00 $410.00 | 3 | |
镁离子作为辅助因子对许多酶促反应至关重要。硫酸镁可以提供这些离子,如果ERICH2需要镁,则可以稳定其结构并增强其酶促功能。 | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
如果ERICH2受到酪氨酸磷酸化的调节,那么正钒酸钠会抑制蛋白酪氨酸磷酸酶,从而导致ERICH2保持磷酸化状态。 |