CCDC35 activators are a class of compounds that enhance the activity of the CCDC35 (coiled-coil domain-containing 35) protein, which is involved in various cellular functions, particularly those related to the cytoskeleton and intracellular organization. CCDC35 is known to contribute to the structural integrity of the cell, helping to coordinate the formation and stability of microtubules and other cytoskeletal elements. Activators of CCDC35 typically work by enhancing the protein's interactions with other cytoskeletal proteins or stabilizing its conformation, thus promoting its role in organizing cellular structures. These compounds help to elucidate how CCDC35 modulates the dynamics of cytoskeletal organization, including processes such as cell division, migration, and intracellular transport.
The mechanism of action for CCDC35 activators often involves binding to allosteric sites on the protein or facilitating interactions between CCDC35 and its cellular partners. By increasing CCDC35 activity, these activators allow for a more robust exploration of its contributions to cellular architecture and mechanical stability. Researchers use CCDC35 activators to study the protein's role in maintaining the cytoskeletal network and how it influences the behavior of cells under various physiological conditions. By modulating CCDC35 activity, these activators help in understanding the broader implications of cytoskeletal regulation in processes like cell shape maintenance, polarity, and intracellular organization, providing insights into how cells maintain their structure and respond to mechanical stimuli.
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
佛司可林可直接刺激腺苷酸环化酶,从而提高细胞中的环磷酸腺苷(cAMP)水平。升高的 cAMP 会激活 PKA(蛋白激酶 A),然后使包括 CCDC35 在内的目标蛋白磷酸化,导致其激活。 | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
异丙肾上腺素是一种β-肾上腺素能激动剂,可与β-肾上腺素能受体结合并激活其,从而增加细胞内cAMP水平。cAMP通路的这种激活可导致PKA激活,后者可磷酸化并激活CCDC35。 | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX 是磷酸二酯酶(PDEs)的非选择性抑制剂,可通过阻止其分解来提高 cAMP 水平。较高的 cAMP 水平可激活 PKA,进而导致 CCDC35 的磷酸化和激活。 | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
前列腺素E1(PGE1)激活其G蛋白偶联受体,从而通过激活腺苷酸环化酶增加cAMP的产生。这种cAMP可以激活蛋白激酶A(PKA),从而可能引发CCDC35的磷酸化并激活。 | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
阿尼霉素是一种蛋白质合成抑制剂,它还能激活应激激活蛋白激酶(SAPK),如JNK。这种激酶激活可导致转录因子和其他蛋白的激活,其中下游靶点可能包括CCDC35。 | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
二丁酰环磷酸腺苷是一种可穿透细胞膜的环磷酸腺苷类似物,可直接激活环磷酸腺苷依赖性通路。进入细胞后,它激活蛋白激酶A,后者可能磷酸化CCDC35,从而激活该蛋白。 | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
冈田酸是蛋白磷酸酶 PP1 和 PP2A 的强效抑制剂,由于其去磷酸化作用受到抑制,这可能会导致蛋白磷酸化水平升高。这会导致 CCDC35 等受磷酸化调控的蛋白质持续活化。 | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
肾上腺素(又称肾上腺素)与肾上腺素能受体结合并激活受体,从而增加 cAMP 的产生并激活 PKA。然后,PKA 可以磷酸化各种靶标,可能包括 CCDC35,从而导致其活化。 | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
罗利普仑是 PDE4 的选择性抑制剂,PDE4 可降解 cAMP。抑制 PDE4 会导致 cAMP 水平升高,从而激活 PKA。然后,PKA 会磷酸化并激活 CCDC35。 | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
扎普瑞纳特是一种 PDE5 选择性抑制剂,PDE5 主要分解 cGMP,但也能影响 cAMP 水平。抑制 PDE5 可能会导致 PKA 活性的改变,从而可能导致 CCDC35 的磷酸化和激活。 |