β5 Tubulin Inhibitors
Chemical inhibitors of β5 Tubulin disrupt the protein's pivotal role in microtubule dynamics, which are essential components of the cellular cytoskeleton. Colchicine, for instance, binds to tubulin and inhibits its polymerization into microtubules, effectively halting the assembly and function of these structures. Similarly, Vincristine targets β5 Tubulin and prevents its polymerization, leading to a pause in cell division processes. Podophyllotoxin exerts its action by binding to β5 Tubulin and stabilizing the tubulin monomer, thereby inhibiting polymerization and microtubule formation.
Further disrupting β5 Tubulin's function, Nocodazole impedes microtubule networks by binding to β5 Tubulin and inhibiting its polymerization. Combretastatin A4, by binding at the colchicine site, similarly inhibits the polymerization of tubulin, directly impairing the function of β5 Tubulin in microtubule formation. Eribulin mesylate takes a unique approach by binding to the plus ends of microtubules, affecting β5 Tubulin's role in microtubule growth and leading to cell cycle arrest. Dolastatin 10 binds to β5 Tubulin; it inhibits microtubule polymerization, resulting in the disruption of β5 Tubulin's normal function. Vinflunine binds at the vinca domain of tubulin and impedes microtubule dynamics, thereby inhibiting β5 Tubulin. Lastly, Maytansine, by binding to the rhizoxin binding site on tubulin, inhibits the polymerization of β5 Tubulin, preventing the essential formation of microtubules for cell mitosis. Each of these chemical inhibitors, through their interaction with β5 Tubulin, impairs the formation and function of microtubules, a critical component of the cellular cytoskeleton and cell division.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, specifically β-tubulin, inhibiting its polymerization into microtubules, thereby disrupting microtubule assembly and function. This directly inhibits β5 Tubulin by preventing its incorporation into functional microtubules. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin binds to tubulin, inhibiting the assembly of microtubule structures. It has a high affinity for β-tubulin and would thus inhibit the function of β5 Tubulin by stabilizing the tubulin monomer and preventing polymerization. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule networks by binding to β-tubulin and inhibiting its polymerization. This effect on microtubules directly inhibits the function of β5 Tubulin, which is critical for microtubule formation. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combretastatin A4 binds to tubulin at the colchicine site and inhibits its polymerization. This action directly inhibits the function of β5 Tubulin by preventing it from forming microtubules, thus impairing cell division. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin mesylate inhibits the growth phase of microtubules by binding preferentially to plus ends, affecting β-tubulin, including β5 Tubulin, leading to cell cycle arrest and apoptosis. | ||||||
Dolastatin 10 | 110417-88-4 | sc-507413 | 5 mg | $980.00 | ||
Dolastatin 10 inhibits tubulin polymerization by binding to the vinca peptide binding site on β-tubulin. It specifically inhibits the function of β5 Tubulin by preventing its integration into microtubules. | ||||||
Vinflunine | 162652-95-1 | sc-507411 | 10 mg | $390.00 | ||
Vinflunine binds to tubulin at the vinca domain and inhibits microtubule dynamics. This inhibits the function of β5 Tubulin by preventing the proper assembly and disassembly of microtubules necessary for cell functions. | ||||||
Maytansine | 35846-53-8 | sc-507510 | 100 mg | $1000.00 | ||
Maytansine binds to tubulin at the rhizoxin binding site and inhibits its polymerization. This directly inhibits the function of β5 Tubulin by preventing the formation of microtubules, which are essential for cell mitosis. | ||||||