t-Butylhydroquinone t-Butylhydroquinone is a phenolic antioxidant functioning as an inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) and ERK2 activator.

t-Butylhydroquinone  (CAS 1948-33-0)

t-Butylhydroquinone is rated 5.0 out of 5 by 1.
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Synonym: TBHQ; 2-tert-butylbenzene-1,4-diol
Application: An inhibitor of the endoplasmic reticulum Ca2+-ATPase and activator of ERK2
CAS Number: 1948-33-0
Purity: ≥97%
Molecular Weight: 166.22
Molecular Formula: C10H14O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
t-Butylhydroquinone sc-202825 10 g $31.00

t-Butylhydroquinone is a phenolic antioxidant functioning as an inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase). In addition, t-Butylhydroquinone activates ERK2 (extracellular signal-regulated protein kinase 2) which was late and prolonged compared to butylated hydroxyanisole (sc-252527), a similar phenolic antioxidant. Moreover, studies suggest that t-Butylhydroquinone requires the help of an upstream signaling kinase MAPK/ERK kinase (MEK) in order to activate ERK2. It has been reported that t-Butylhydroquinone reduces the intracellular concentration of H2O2 which are byproducts generated during the MAPK pathway. Alternate studies indicate that t-Butylhydroquinone can increase cytosolic and mitochondrial thioredoxin reductase activity in cortical astrocytes.


References

1. Yu, R., et al. 1997. J. Biol. Chem. 272: 28962-28970. PMID: 9360968
2. Eftekharpour, E., et al. 2000. Glia. 31: 241-248. PMID: 10941150

Physical State :
Solid
Solubility :
Soluble in DMSO, methanol, water (10 g/l) at 20° C, acetone, ethanol, ethyl acetate, and propylene glycol (30 %) at 25° C. Solubility in fats and food-grade solvents is good. Insoluble in benzene.
Storage :
Store at room temperature
Melting Point :
127-129° C (lit.)
Boiling Point :
295° C at 760 mmHg
Density :
1.05 g/cm3 at 20° C
Refractive Index :
n20D 1.55 (Predicted)
pK Values :
pKa: 10.80
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MX4375000
PubChem CID :
16043
MDL Number :
MFCD00002344
EC Number :
217-752-2
Beilstein Registry :
637923
SMILES :
CC(C)(C)C1=C(C=CC(=C1)O)O

Download SDS (MSDS)

Certificate of Analysis

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Hello, I am doing a project for my chemistry class. I need to know who discovered TBHQ, when was it discovered, and what products was it originally used in. I cannot find this information anywhere.

Asked by: David1
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Rated 5 out of 5 by from Galloway Galloway, et al. (PubMed ID: 9359839) showed that treatment with t-Butylhydroquinone can increase the concentration of glutithione in HepG2 cells. -SCBT Publication Review
Date published: 2015-01-17
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