Molecular structure of t-Butylhydroquinone, CAS Number: 1948-33-0
t-Butylhydroquinone (CAS 1948-33-0)
See product citations (4)
Alternate Names:
TBHQ; 2-tert-butylbenzene-1,4-diol
Application:
t-Butylhydroquinone is an inhibitor of the endoplasmic reticulum Ca2+-ATPase and activator of ERK2
CAS Number:
1948-33-0
Purity:
≥97%
Molecular Weight:
166.22
Molecular Formula:
C10H14O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
t-Butylhydroquinone is a phenolic antioxidant functioning as an inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase). In addition, t-Butylhydroquinone activates ERK2 (extracellular signal-regulated protein kinase 2) which was late and prolonged compared to butylated hydroxyanisole (sc-252527), a similar phenolic antioxidant. Moreover, studies suggest that t-Butylhydroquinone requires the help of an upstream signaling kinase MAPK/ERK kinase (MEK) in order to activate ERK2. It has been reported that t-Butylhydroquinone reduces the intracellular concentration of H2O2 which are byproducts generated during the MAPK pathway. Alternate studies indicate that t-Butylhydroquinone can increase cytosolic and mitochondrial thioredoxin reductase activity in cortical astrocytes.
t-Butylhydroquinone (CAS 1948-33-0) References
- Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells. | Bock, KW., et al. 2000. Biochem Pharmacol. 59: 467-70. PMID: 10660112
- Thioredoxin reductase and glutathione synthesis is upregulated by t-butylhydroquinone in cortical astrocytes but not in cortical neurons. | Eftekharpour, E., et al. 2000. Glia. 31: 241-8. PMID: 10941150
- Influence of t-butylhydroquinone and beta-naphthoflavone on formation and transport of 4-methylumbelliferone glucuronide in Caco-2/TC-7 cell monolayers. | Bock-Hennig, BS., et al. 2002. Biochem Pharmacol. 63: 123-8. PMID: 11841785
- Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathway. | Auyeung, DJ., et al. 2003. Mol Pharmacol. 63: 119-27. PMID: 12488544
- Regulation of the glyoxalase pathway in human brain microvascular endothelium: effects of troglitazone and tertiary butylhydroperoxide. | Wu, L., et al. 2002. Endothelium. 9: 273-8. PMID: 12572858
- Regulation of NAD(P)H:quininone oxidoreductase by glucocorticoids. | Pinaire, JA., et al. 2004. Toxicol Appl Pharmacol. 199: 344-53. PMID: 15364549
- Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes. | Tamaki, H., et al. 2005. Toxicology. 216: 224-31. PMID: 16169145
- Effects of astaxanthin in obese mice fed a high-fat diet. | Ikeuchi, M., et al. 2007. Biosci Biotechnol Biochem. 71: 893-9. PMID: 17420580
- Promoting Effect of α-Tocopherol on Beige Adipocyte Differentiation in 3T3-L1 Cells and Rat White Adipose Tissue. | Tanaka-Yachi, R., et al. 2017. J Oleo Sci. 66: 171-179. PMID: 28154348
- Activation of protease-activated receptor 4 of mast cells could downregulate proinflammatory cytokines in irritable bowel syndrome. | An, S., et al. 2017. Gut. 66: 2040-2042. PMID: 28274996
- Bcl-2-associated athanogene 5 overexpression attenuates catecholamine-induced vascular endothelial cell apoptosis. | Zhu, H., et al. 2021. J Cell Physiol. 236: 946-957. PMID: 32583430
- Cellular uptake of lead is activated by depletion of intracellular calcium stores. | Kerper, LE. and Hinkle, PM. 1997. J Biol Chem. 272: 8346-52. PMID: 9079658
- Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants. | Yu, R., et al. 1997. J Biol Chem. 272: 28962-70. PMID: 9360968
Inhibitor of:
C16orf57, DDX40, GSTT4, KCC4, KIAA0776, MGST1, and SERCA.Activator of:
20S Proteasome α7, 20S Proteasome β1, AKR7, AKR7A5, Ces1g, CMBL, ERK 2, Fv1, G6pd2, GCSH, Glutathione reductase, GPx-1, GPx-4, GPx-5, GPx-7, Gsta1, GSTA3, GSTA4, GSTA5, GSTCD, GSTM4, GSTO2, Gstp2, GSTT2B, GSTT4, Keap1, KSP37, MafK, Metallothionein 1G, Metallothionein 2A, MGC87042, MGST3, MRP-S17, MRP3, NAT-13, NF-E2, Nox4, Nrf3, Nucleoredoxin, NXNL2, OKL38, polycyclic aromatic hydrocarbons, POT1, PRX I, PRX II, PRX V, SAA4, Selenoprotein M, Selenoprotein W, SEP15, SKN-1, SOD-1, SOD-2, SPTRX-3, Sulfiredoxin, SULT1A2, TMUB2, TR2IT1, TRP14, Trx, TXNDC10, UCH-L1, UGT1A9, and UGT2B37.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
t-Butylhydroquinone, 10 g | sc-202825 | 10 g | $66.00 |