Date published: 2025-10-4

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Sinensetin (CAS 2306-27-6)

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Alternate Names:
Pedalitin Permethyl Ether
Application:
Sinensetin is an inhibitor of linoleic acid oxidation
CAS Number:
2306-27-6
Molecular Weight:
372.37
Molecular Formula:
C20H20O7
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sinensetin is a polymethoxylated flavone, primarily found in certain citrus fruits and herbs, which has been widely studied in the context of biochemical and agricultural research. This compound is distinguished by its structure, consisting of a flavone backbone with multiple methoxy groups that enhance its chemical stability and influence its interaction with biological systems. In research settings, sinensetin′s mechanisms of action have been explored for their effects on enzyme activity and gene expression in plants. It has been particularly noted for its ability to modulate the activity of enzymes involved in the biosynthesis of plant secondary metabolites. This modulation can affect plant growth and defense mechanisms, making sinensetin a valuable compound in studies focused on plant resilience and adaptation. Additionally, sinensetin has been employed in studies investigating its role as a natural antioxidant. Its structure allows it to scavenge free radicals and protect cellular components from oxidative stress, which is crucial for understanding the aging processes in plants and their responses to environmental stresses. Moreover, the compound′s interaction with cellular receptors and signaling pathways has provided insights into how plants communicate internally and with their environment. These interactions are crucial for developing strategies to enhance crop protection and yield, particularly through the development of bioactive compounds derived from natural sources.


Sinensetin (CAS 2306-27-6) References

  1. Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma.  |  Tan, KT., et al. 2019. Anticancer Drugs. 30: 485-494. PMID: 30702500
  2. Sinensetin suppresses influenza a virus-triggered inflammation through inhibition of NF-κB and MAPKs signalings.  |  Li, J., et al. 2020. BMC Complement Med Ther. 20: 135. PMID: 32370749
  3. Sinensetin: An Insight on Its Pharmacological Activities, Mechanisms of Action and Toxicity.  |  Han Jie, L., et al. 2020. Front Pharmacol. 11: 553404. PMID: 33628166
  4. Sinensetin attenuates oxygen-glucose deprivation/reperfusion-induced neurotoxicity by MAPK pathway in human cerebral microvascular endothelial cells.  |  Yang, D., et al. 2022. J Appl Toxicol. 42: 683-693. PMID: 34664717
  5. Sinensetin suppresses angiogenesis in liver cancer by targeting the VEGF/VEGFR2/AKT signaling pathway.  |  Li, X., et al. 2022. Exp Ther Med. 23: 360. PMID: 35493423
  6. Sinensetin protects against pulmonary fibrosis via inhibiting Wnt/β-Catenin signaling pathway.  |  Wan, X., et al. 2022. Tissue Cell. 78: 101866. PMID: 35907344
  7. Natural flavonoid sinensetin inhibits cisplatin-induced pyroptosis and attenuates intestinal injury.  |  Li, Y., et al. 2023. Biochim Biophys Acta Mol Basis Dis. 1869: 166637. PMID: 36638874
  8. Dietary sinensetin and polymethoxyflavonoids: Bioavailability and potential metabolic syndrome-related bioactivity.  |  Zhang, M., et al. 2023. Crit Rev Food Sci Nutr. 1-17. PMID: 37283048
  9. Sinensetin Attenuated Macrophagic NLRP3 Inflammasomes Formation via SIRT1-NRF2 Signaling.  |  Lin, L., et al. 2023. ACS Omega. 8: 33514-33525. PMID: 37744845
  10. Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition.  |  Zhu, S., et al. 2024. Transl Cancer Res. 13: 348-362. PMID: 38410229

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sinensetin, 10 mg

sc-473951
10 mg
$556.00