Silydianin (CAS 29782-68-1)
CAS Number:
29782-68-1
Molecular Weight:
482.44
Molecular Formula:
C25H22O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Silydianin holds profound significance due to its polyphenolic nature and diverse array of biological activities. Functioning as a modulator, silydianin is postulated to influence the behavior of several enzymes and proteins. Scientific investigations have revealed its potential to inhibit the activity of enzymes associated with inflammation, such as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX). Furthermore, silydianin displays inhibitory effects on proteins that regulate cellular processes like proliferation and apoptosis, including Bcl-2 and caspase-3.
Silydianin (CAS 29782-68-1) References
- An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. | Zielińska-Przyjemska, M. and Wiktorowicz, K. 2006. Phytother Res. 20: 115-9. PMID: 16444663
- Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry. | Lee, JI., et al. 2006. J Chromatogr A. 1116: 57-68. PMID: 16631762
- Silymarin and its components scavenge phenylglyoxylic ketyl radicals. | Sersen, F., et al. 2006. Fitoterapia. 77: 525-9. PMID: 16956731
- Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity. | Pyszková, M., et al. 2016. Free Radic Biol Med. 90: 114-25. PMID: 26582372
- Phototoxic potential of silymarin and its bioactive components. | Rajnochová Svobodová, A., et al. 2016. J Photochem Photobiol B. 156: 61-8. PMID: 26851710
- Metabolism of flavonolignans in human hepatocytes. | Vrba, J., et al. 2018. J Pharm Biomed Anal. 152: 94-101. PMID: 29414024
- Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. | Qin, N., et al. 2018. J Enzyme Inhib Med Chem. 33: 1283-1291. PMID: 30160205
- Skin Protective Activity of Silymarin and its Flavonolignans. | Vostálová, J., et al. 2019. Molecules. 24: PMID: 30875758
- A pilot study of the UVA-photoprotective potential of dehydrosilybin, isosilybin, silychristin, and silydianin on human dermal fibroblasts. | Rajnochová Svobodová, A., et al. 2019. Arch Dermatol Res. 311: 477-490. PMID: 31079190
- Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans. | Vrba, J., et al. 2020. J Pharm Biomed Anal. 178: 112972. PMID: 31727359
- Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota. | Valentová, K., et al. 2020. Metabolites. 10: PMID: 31936497
- Immunomodulatory effects of two silymarin isomers in a Balb/c mouse model of allergic asthma. | Nasab, EM., et al. 2020. Allergol Immunopathol (Madr). 48: 646-653. PMID: 32284261
- Development of a capillary electrophoresis method for the separation of flavonolignans in silymarin complex. | Riasová, P., et al. 2022. Electrophoresis. 43: 930-938. PMID: 34751959
- Nanoemulsions prepared from mountain ginseng-mediated gold nanoparticles and silydianin increase the anti-inflammatory effects by regulating NF-κB and MAPK signaling pathways. | Tran, THM., et al. 2022. Biomater Adv. 137: 212814. PMID: 35929253
- Structural basis of Nrf2 activation by flavonolignans from silymarin. | Bello, M. 2023. J Mol Graph Model. 119: 108393. PMID: 36525840
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Silydianin, 10 mg | sc-473926 | 10 mg | $475.00 |