Cancer stems cells (CSCs) are a subpopulation of cells within tumors that drive tumor growth and recurrence. They are resistant to many current cancer treatments. Salinomycin (sodium salt) is an antibacterial and coccidiostat compound that shows selective toxicity for the CSCs that exist as a subpopulation within HMLER breast cancer cells (IC50s = ~24 versus ~90 μM).1 At 8 μM, salinomycin treatment of 4T1 and MCF7Ras breast cancer cell lines results in a ~2-fold and ~3-fold, respective reduction of CSCs relative to controls.1 Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial differentiation of tumor cells.
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
Please can you inform me over the purity of the product salinomycin sc236851?
Asked by: Gerrit
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot. Please call our European Support office toll-free at 00800 4573 8000, email email@example.com, or contact us by live chat.
Rated 5 out of
Salinomycin monosodium salt - 100 mgI bought the above mentioned product few weeks ago. Both the product and its backing was in excellent condition. The service was also great. I am so happy with Santa Cruz Biotechnology product and their service.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.