S-Nitrosoglutathione (GSNO) A spontaneously releasing nitric oxide donor which inhibits NFκB and platelet activation

S-Nitrosoglutathione (GSNO) (CAS 57564-91-7)

S-Nitrosoglutathione (GSNO) | CAS 57564-91-7 is rated 5.0 out of 5 by 1.
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Synonym: SNOG;N- (N-L-γ-glutamyl-S-nitroso-L-cysteinyl)-glycine
Application: A spontaneously releasing nitric oxide donor which inhibits NFκB and platelet activation
CAS Number: 57564-91-7
Purity: ≥98%
Molecular Weight: 336.32
Molecular Formula: C10H16N4O7S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

S-Nitrosoglutathione (GSNO), an amino acid nitric oxide donor, when under physiological conditions spontaneously releases nitric oxide. In research it has been observed to selectively inhibit platelet activation and display cardioprotective effects. This product also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). GNSO has demonstrated dose dependent effects on Thymocytes by inducing apoptosis in T cells in low concentrations (< 0.6 mM), while protecting T cells from apoptosis in higher concentrations (1-2 mM).


References

1. Konorev, E A., et al., 1995. S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide. The Journal of pharmacology and experimental therapeutics. 274(1): 200-6. PMID: 7616400
2. Peng, H B., et al., 1995. Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells. The Journal of biological chemistry. 270(28): 17050-5. PMID: 7622526
3. Sarkar, R., et al., 1995. Nitric oxide inhibition of endothelial cell mitogenesis and proliferation. Surgery. 118(2): 274-9. PMID: 7638744
4. Peng, H B., et al., 1995. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. The Journal of biological chemistry. 270(23): 14214-9. PMID: 7775482
5. Mathews, W R., et al., 1993. Biological activity of S-nitrosothiols: the role of nitric oxide. The Journal of pharmacology and experimental therapeutics. 267(3): 1529-37. PMID: 7903392
6. de Belder, A J., et al., 1994. Effects of S-nitroso-glutathione in the human forearm circulation: evidence for selective inhibition of platelet activation. Cardiovascular research. 28(5): 691-4. PMID: 8025915
7. Sandau, K., et al., 1996. The dual role of S-nitrosoglutathione (GSNO) during thymocyte apoptosis. Cellular signalling. 8(3): 173-7. PMID: 8736700
8. Ascenzi, P., et al., 2001. Inhibition of cysteine protease activity by NO-donors. Current protein & peptide science. 2(2): 137-53. PMID: 12370021

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), DMSO (20 mg/ml), and PBS. Insoluble in 100% ethanol, methanol, and DMF.
Storage :
Store at -20° C
Melting Point :
329.14° C (Predicted)
Boiling Point :
651.98° C (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.66
IC50 :
Rattus norvegicus: EC5050 = 107.5 nM
Ki Data :
Human rhinovirus 14: Ki= 360 µM
pK Values :
pKa: 2.21, pKb: 9.28
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MC0558000
PubChem CID :
104858
MDL Number :
MFCD00214341
EC Number :
248-170-7
Beilstein Registry :
3566211
SMILES :
C(CC(=O)N[C@@H](CSN=O)C(=O)NCC(=O)O)[C@@H](C(=O)O)N

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Certificate of Analysis

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S-Nitrosoglutathione (GSNO)  Product Citations

See how others have used S-Nitrosoglutathione (GSNO). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 27082706  Li, R. et al. 2016. The journal of trauma and acute care surgery. 80: 440-9.

PMID: # 27095671  Kumar, A. et al. 2016. Biochimica et biophysica acta. 1860: 1519-27.

PMID: # 25749567  Bradley, SA. et al. 2015. J. Neurosci. Methods. 245: 116-24.

PMID: # 25115184  Soetkamp, D. et al. 2014. Basic Res. Cardiol. 109: 433.

PMID: # 25019574  Fujita, M. et al. 2014. FEBS Lett. 588: 3240-50.

PMID: # 22554503  Yuan, H. et al. 2012. Biochem. Biophys. Res. Commun. 421: 134-9.

Citations 1 to 6 of 6 total

which of you're suggested solvent is better? because I had problem in solve. I work in invitro physiological conditions.

Asked by: mostashfi
Thank you for your question. S-Nitrosoglutathione (GSNO): sc-200349 is soluble in water (25 mg/ml), DMSO (20 mg/ml), and PBS. It is insoluble in 100% ethanol, methanol, and DMF. If you are having trouble getting this into solution, please contact our Technical Service Department for more support. Please be prepared to provide the lot number you received. Please call us toll-free at (800) 457-3801 option 2, e-mail scbt@scbt.com, or use our live chat.
Answered by: Technical Support
Date published: 2017-09-28

And what about half life in aqueous media ?

Asked by: Ivona
Thank you for your question. This chemical, S-Nitrosoglutathione (GSNO) (CAS 57564-91-7), has a half-life of 159 hours under physiological conditions.
Answered by: Technical Support
Date published: 2017-09-24

What is the half-life of this compound?

Asked by: Marietha
Thank you for your question. S-Nitrosoglutathione (GSNO) (CAS 57564-91-7) has a half-life of 159 hours under physiological conditions.
Answered by: Technical Support
Date published: 2017-07-26
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Rated 5 out of 5 by from Erickson Erickson, JR. et al. (PubMed 26316536) found parallel effects of GSNO, a NO donor, on CaM/CaMKII binding and CaMKII -dependent ryanodine receptor activation in adult cardiac myocytes. They concluded that NO can play a dual role in regulating cardiac CaMKII activity. -SCBT Publication Review
Date published: 2015-02-05
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