Molecular structure of Pregnenolone sulfate sodium salt, CAS Number: 1852-38-6
Pregnenolone sulfate sodium salt (CAS 1852-38-6)
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Alternate Names:
3β-Hydroxy-5-pregnen-20-one 3-sulfate; 3-Hydroxypregn-5-en-20-one sulfate; 5-Pregnen-3β-ol-20-one sulfate
Application:
Pregnenolone sulfate sodium salt is is a GABAA receptor antagonist
CAS Number:
1852-38-6
Molecular Weight:
418.52
Molecular Formula:
C21H31NaO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Pregnenolone sulfate sodium salt (PSS) represents a steroidal compound that originates within the body and functions as a precursor to other hormones. As a naturally occurring metabolite, it actively participates in a diverse array of physiological processes. While the precise mechanism of action for Pregnenolone sulfate sodium salt remains incompletely elucidated, it is established that Pregnenolone sulfate sodium salt binds to various receptors and modulates the activity of enzymes involved in lipid, carbohydrate, and protein metabolism. Moreover, it has been discovered that Pregnenolone sulfate sodium salt exerts influence on gene expression related to energy metabolism.
Pregnenolone sulfate sodium salt (CAS 1852-38-6) References
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- Is connexin36 critical for GABAergic hypersynchronization in the hippocampus? | Beaumont, M. and Maccaferri, G. 2011. J Physiol. 589: 1663-80. PMID: 21300748
- The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats. | Dastgheib, M., et al. 2015. Neuroscience. 306: 1-9. PMID: 26272534
- Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3. | Siroky, BJ., et al. 2017. Am J Physiol Renal Physiol. 312: F791-F805. PMID: 28122715
- Viability Screen of LOPAC1280 Reveals Phosphorylation Inhibitor Auranofin as a Potent Inhibitor of Blastocystis Subtype 1, 4, and 7 Isolates. | Yason, JA., et al. 2018. Antimicrob Agents Chemother. 62: PMID: 29866860
- Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells. | Fujiki, J., et al. 2018. Steroids. 138: 64-71. PMID: 30018003
- The TRPP2-dependent channel of renal primary cilia also requires TRPM3. | Kleene, SJ., et al. 2019. PLoS One. 14: e0214053. PMID: 30883612
- Comparison of Strategies for the Determination of Sterol Sulfates via GC-MS Leading to a Novel Deconjugation-Derivatization Protocol. | Junker, J., et al. 2019. Molecules. 24: PMID: 31247920
- Improvement of Remyelination in Demyelinated Corpus Callosum Using Human Adipose-Derived Stem Cells (hADSCs) and Pregnenolone in the Cuprizone Rat Model of Multiple Sclerosis. | Ganji, R., et al. 2020. J Mol Neurosci. 70: 1088-1099. PMID: 32314194
- Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents. | Tan, HL., et al. 2021. Drug Metab Pharmacokinet. 38: 100390. PMID: 33836300
- Bradykinin-Induced Sensitization of Transient Receptor Potential Channel Melastatin 3 Calcium Responses in Mouse Nociceptive Neurons. | Behrendt, M., et al. 2022. Front Cell Neurosci. 16: 843225. PMID: 35496916
- SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1. | Tomabechi, R., et al. 2022. PNAS Nexus. 1: pgac063. PMID: 36741448
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Inhibitor of:
GABA Receptor, and Kir3.Activator of:
βENaC, ABCA14, ABCA15, BSDC1, CaMKIIγ, CAPS1, Caytaxin, dendrin, EG667292, EG667512, Enkurin, GABAA Rε, GABAA Rγ2, GABAA Rρ1, GALP, GlyR α1 (GLRA1), GRIN2, Gtlf3b, HMX2, KIAA1737, L-type Ca++ CP α1D, L-type calcium channel α1F, M6A, mGluR-7, Mrgprx3, NaGLT1, neugrin, NMDA, NMDAε2, Olr263, Olr267, Olr270, Olr282, Olr29, Olr307, Olr32, Olr326, Olr34, Olr354, Olr358, Olr361, SIM1, SLC22A14, Slc22a27, Syncytin, TALK-2, TMEM206, TRESK, Unc79, VMAT 2, Vmn1r60, Vmn1r90, Vmn1r91, and Vmn2r13.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pregnenolone sulfate sodium salt, 50 mg | sc-301609 | 50 mg | $97.00 |