Pregnenolone A prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids

Pregnenolone (CAS 145-13-1)

Pregnenolone | CAS 145-13-1 is rated 5.0 out of 5 by 1.
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Synonym: Δ5-Pregenen-3β-ol-20-one; 3β-Hydroxy-5-pregenen-20-one; Arthenolone; Skinostelon; Enelone; Pregnetan; Pregneton; Pregnolon; Prenolon; Regnosone
Application: A prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids
CAS Number: 145-13-1
Molecular Weight: 316.48
Molecular Formula: C21H32O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR.


References

Shen W, Mennerick S, Covey DF, Zorumski CF. J Neurosci. 20:3571-9 (2000). Cascio C, Guarneri R, Russo D et al. J Neurochem. 74:2380-91(Grigoryev DN, Long BJ, Njar VC, Brodie AH. J Steroid Biochem Mol Biol. 75:1-10 (2000).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol (22 mg/ml at 25° C), chloroform, and DMSO (22 mg/ml at 25° C). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
190-192° C
Boiling Point :
443.26° C at 760 mmHg (Predicted)
Density :
1.09 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
Optical Activity :
α20/D 28.5°±1.5°, c = 1 in ethanol
IC50 :
G6PD: IC50 = 81.4 µM (human); CYP51A1: IC50 = >200 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TU5560700
PubChem CID :
8955
Merck Index :
14: 7733
MDL Number :
MFCD00003628
EC Number :
205-647-4
Beilstein Registry :
2059026
SMILES :
CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Gaignard Gaignard, P. et al. (PubMed 26039154) investigated the effect of sex differences on brain mitochondrial function and its suppression by ovariectomy and in aged mice. Their findings suggest that the major male/female differences in brain Pregnenolone and progesterone levels may contribute to sex differences observed in brain mitochondrial function. -SCBT Publication Review
Date published: 2015-03-07
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