NDGA (Nordihydroguaiaretic acid) is an anti-oxidant 5-LO (5-lipoxygenase) inhibitor lignan found in Larrea tridentata. NDGA has been shown to synergistically enhanced the cytotoxicity of DOX, CPT and MTX on tumor cells. NDGA has been shown to inhibit the TGFβ R1 (TGF-β type 1 receptor) by repressing Smad2 phosphorylation. NDGA has displayed antimutagenic effects in a number of cell models through proposed action as a chain-breaking antioxidant. NDGA has also displayed antimicrobial activity. Additionally, this compound is an inhibitor of epidermal and hepatic CYP (cytochrome P450).
1. Lambert, J.D., et al. 2002. Toxicon. 40: 1701-1708. PMID: 12457882 2. Meyers, R.O., et al. 2009. Bioorg. Med. Chem. Lett. 19: 4752-4755. PMID: 19615898 3. Plaza, C., et al. 2009. In Vivo. 23: 959-967. PMID: 20023240 4. Chu, L.S., et al. 2010. Sheng Li Xue Bao. 62: 101-108. PMID: 20401443
Soluble in 100% ethanol, methanol, acetone, DMSO, DMF, ethanol (5% w/v), glycol, PEG, and slightly soluble in hot water. Insoluble in water.
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ZhangZhang, X. et al. (PubMed 26311402) reported that combination of amniotic epithelial cells (AECs) with NDGA (Nordihydroguaiaretic acid; Dihydronorguaiaretic acid; nordihydroguaiaretate), an antioxidant and lipoxygenase inhibitor, promotes the survival of transplanted AECs in spinal cord-injured rats. -SCBT Publication Review
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