Molecular structure of NDGA (Nordihydroguaiaretic acid), CAS Number: 500-38-9
NDGA (Nordihydroguaiaretic acid) (CAS 500-38-9)
See product citations (3)
Alternate Names:
Dihydronorguaiaretic acid; nordihydroguaiaretate
Application:
NDGA (Nordihydroguaiaretic acid) is an antioxidant and lipoxygenase inhibitor
CAS Number:
500-38-9
Purity:
≥95%
Molecular Weight:
302.36
Molecular Formula:
C18H22O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NDGA (Nordihydroguaiaretic acid) is a compound of interest in various research domains, particularly due to its role as a lipoxygenase inhibitor, which makes it useful for studying the metabolism of arachidonic acid and related inflammatory pathways. The ability of NDGA (Nordihydroguaiaretic acid) to block the synthesis of leukotrienes and other hydroperoxides offers a window into the cellular processes underpinning inflammation and oxidative stress. Its antioxidant properties are leveraged in studies aimed at understanding the mechanisms of cellular protection against oxidative damage. Additionally, NDGA (Nordihydroguaiaretic acid) is used to investigate its modulatory effects on various signaling pathways, including those involved in cell growth and apoptosis. This has expanded its application in research concerning the regulation of cell proliferation and survival, providing insights that are applicable across a range of biological applications.
NDGA (Nordihydroguaiaretic acid) (CAS 500-38-9) References
- Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. | Lambert, JD., et al. 2002. Toxicon. 40: 1701-8. PMID: 12457882
- Oxidation of the lignan nordihydroguaiaretic acid. | Billinsky, JL., et al. 2007. Chem Res Toxicol. 20: 1352-8. PMID: 17672511
- Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid. | Meyers, RO., et al. 2009. Bioorg Med Chem Lett. 19: 4752-5. PMID: 19615898
- Nordihydroguaiaretic acid analogues: their chemical synthesis and biological activities. | Chen, Q. 2009. Curr Top Med Chem. 9: 1636-59. PMID: 19903157
- Chemosensitizing effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on parental and multiresistant TA3 mouse mammary adenocarcinoma cells. | Plaza, C., et al. 2009. In Vivo. 23: 959-67. PMID: 20023240
- [Nordihydroguaiaretic acid partially inhibits inflammatory responses after focal cerebral ischemia in rats]. | Chu, LS., et al. 2010. Sheng Li Xue Bao. 62: 101-8. PMID: 20401443
- Antiviral Activity of Nordihydroguaiaretic Acid and Its Derivative Tetra-O-Methyl Nordihydroguaiaretic Acid against West Nile Virus and Zika Virus. | Merino-Ramos, T., et al. 2017. Antimicrob Agents Chemother. 61: PMID: 28507114
- Effect of nordihydroguaiaretic acid on spermatogenesis and fertility in rats. | Abbas, MA., et al. 2018. Andrologia. 50: PMID: 29110321
- Nordihydroguaiaretic acid can suppress progression of experimental autoimmune encephalomyelitis. | Wang, L., et al. 2018. IUBMB Life. 70: 432-436. PMID: 29637686
- Nordihydroguaiaretic acid prevents glycation induced structural alterations and aggregation of albumin. | Awasthi, S., et al. 2019. Int J Biol Macromol. 122: 479-484. PMID: 30416092
- Nordihydroguaiaretic acid reduces secondary organ injury in septic rats after cecal ligation and puncture. | Zubrow, ME., et al. 2020. PLoS One. 15: e0237613. PMID: 32790786
- First report of antiviral activity of nordihydroguaiaretic acid against Fort Sherman virus (Orthobunyavirus). | Martinez, F., et al. 2021. Antiviral Res. 187: 104976. PMID: 33444704
- Nordihydroguaiaretic Acid as a Novel Substrate and Inhibitor of Catechol O-Methyltransferase Modulates 4-Hydroxyestradiol-Induced Cyto- and Genotoxicity in MCF-7 Cells. | Kim, JH., et al. 2021. Molecules. 26: PMID: 33916785
- Acute catabolism of leukocyte lipid bodies: Characterization of a nordihydroguaiaretic acid (NDGA)-induced proteasomal-dependent model. | de Lira, MN., et al. 2021. Prostaglandins Leukot Essent Fatty Acids. 171: 102320. PMID: 34303171
- The Polyphenols α-Mangostin and Nordihydroguaiaretic Acid Induce Oxidative Stress, Cell Cycle Arrest, and Apoptosis in a Cellular Model of Medulloblastoma. | Rojas-Ochoa, A., et al. 2021. Molecules. 26: PMID: 34885809
Inhibitor of:
12-LO, 15-LO, 15-LO2, 5-LO, A2LD1, Aflatoxin B2, AKR1B15, AKR7, Alox12e, ALOXE3, apoL9b, Arbp, claudin-3, CNOX, COL4A1, COTL1, CTDSPL, CYP, Cyp4f14, Epidermis-type 12-LO, Extensin, FBXW24, Fe65, Fos B, Furin, GPIHBP1, group VI iPLA2, HRASLS2, IGF-IIR, IGF2AS, IGFBP4, IGFBPL1, IGFL2, IL-TIFb, Insulin II, ISGF-3γ p48, LOX, LOXL1, LOXL2, LPCAT1, MsrA, NCB5OR, NEI, Ost1, p47-phox, PECR, Peroxin 2, Reg ll, S-100 α chain, SCD2, SERCA2, TMEM202, TMEM205, TPST-1, TRAF7, Trp3, UGRP2, Vmn2r114, Ym1, and ZO-1.Activator of:
κB-Ras1, AKR1B7, Alox12e, Annexin II, B7-H3, BEAN, C2CD4A, CRIK, CYP4F3, Cypt12, CysLT1 Receptor, Cytokeratin 12, DCAF15, DDX41, DUOX1, DUOX2, EDD, EG432879, EG546638, Factor B, FBXW26, FLAP, GP49A, Id1, mKIAA1530, Myf-5, Nox5, OAS1, oogenesin 2, oogenesin 3, oogenesin 4, p67-phox, PAPP-A, PDGF-C, plexin-B1, RIG-I, SAA3, Smurf2, String, TERT, TRAF4, TREX-1, TTP, UKHC, USP18, and versican.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDGA (Nordihydroguaiaretic acid), 1 g | sc-200487 | 1 g | $107.00 | |||
NDGA (Nordihydroguaiaretic acid), 5 g | sc-200487A | 5 g | $376.00 | |||
NDGA (Nordihydroguaiaretic acid), 25 g | sc-200487B | 25 g | $2147.00 |