Molecular structure of Genistin, CAS Number: 529-59-9
Genistin (CAS 529-59-9)
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Alternate Names:
Genistine; Genistoside; Genistein 7-glucoside
Application:
Genistin is an isoflavone glycoside which is an inactive analog of the PTK inhibitor Genistein
CAS Number:
529-59-9
Purity:
≥99%
Molecular Weight:
432.4
Molecular Formula:
C21H20O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Genistin is an isoflavone glycoside found in soy-based food products. This is an inactive analog of the PTK inhibitor Genistein and can be used as a negative control for Genistein. It has been reported to reduce bone loss in ovarectomized rats. Genistin is a phytoestrogen and an inhibitor of TdT. It may act to modulate the activity of certain enzymes, including COX-2 and MMPs. It also inhibits the growth of certain cancer cells and induces apoptosis. Additionally, Genistin possesses anti-inflammatory, anti-tumor, and anti-oxidant effects.
Genistin (CAS 529-59-9) References
- Excitatory synaptogenesis between identified Lymnaea neurons requires extrinsic trophic factors and is mediated by receptor tyrosine kinases. | Hamakawa, T., et al. 1999. J Neurosci. 19: 9306-12. PMID: 10531435
- Protein tyrosine kinase inhibitors increase cytosolic calcium and inhibit actin organization as resorbing activity in rat osteoclasts. | Kajiya, H., et al. 2000. J Cell Physiol. 183: 83-90. PMID: 10699969
- Comparative study on reduction of bone loss and lipid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzin, genistin, and glycitin. | Uesugi, T., et al. 2001. Biol Pharm Bull. 24: 368-72. PMID: 11305597
- Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. | Russo, A., et al. 2006. J Nutr Biochem. 17: 103-8. PMID: 16111876
- Effect of genistin on bone formation. | Wong, RW. and Rabie, AB. 2010. Front Biosci (Elite Ed). 2: 764-70. PMID: 20036920
- Prevention of rat breast cancer by genistin and selenium. | Hamdy, SM., et al. 2012. Toxicol Ind Health. 28: 746-57. PMID: 22089659
- Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7/NF-κB Pathway. | Gu, M., et al. 2016. Evid Based Complement Alternat Med. 2016: 5381290. PMID: 27087823
- Enterohepatic Circulation and Pharmacokinetics of Genistin and Genistein in Rats. | Yang, YY. and Tsai, TH. 2019. ACS Omega. 4: 18428-18433. PMID: 31720546
- Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway. | Hwang, ST., et al. 2020. Life Sci. 263: 118594. PMID: 33075375
- Genistin modulates high-mobility group box protein 1 (HMGB1) and nuclear factor kappa-B (NF-κB) in Ehrlich-ascites-carcinoma-bearing mice. | Saleh, MA., et al. 2023. Environ Sci Pollut Res Int. 30: 966-978. PMID: 35907070
- Sustainable production of genistin from glycerol by constructing and optimizing Escherichia coli. | Wang, Z., et al. 2022. Metab Eng. 74: 206-219. PMID: 36336175
- Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro. | Liu, M., et al. 2023. Biochem Pharmacol. 209: 115447. PMID: 36746262
- Anabolic effect of genistein and genistin on bone metabolism in the femoral-metaphyseal tissues of elderly rats: the genistein effect is enhanced by zinc. | Yamaguchi, M. and Gao, YH. 1998. Mol Cell Biochem. 178: 377-82. PMID: 9546622
Inhibitor of:
TdT, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Genistin, 5 mg | sc-202168 | 5 mg | $192.00 |