Molecular structure of D-α-Tocopheryl Succinate, CAS Number: 4345-03-3
D-α-Tocopheryl Succinate (CAS 4345-03-3)
Application:
D-α-Tocopheryl Succinate is a potent antioxidant tocopherol
CAS Number:
4345-03-3
Purity:
≥98%
Molecular Weight:
530.80
Molecular Formula:
C33H54O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-alpha-Tocopheryl Succinate is a potent antioxidant tocopherol. At high concentrations it may act to trigger caspase-mediated apoptosis of certain cells and, at low concentrations, inhibit proliferation. Mechanistic studies suggest that this compound down-regulates the fibroblast growth factor receptor-1 (FGFR1). Other experiments report that D-alpha-Tocopheryl Succinate also targets ASK 1, GADD 45beta, and MEK-4, three key components of stress-activated mitogen-activated protein kinase pathway.
D-α-Tocopheryl Succinate (CAS 4345-03-3) References
- RRR-alpha-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest. | Wu, K., et al. 2002. World J Gastroenterol. 8: 26-30. PMID: 11833065
- D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells. | Kumar, B., et al. 2002. J Am Coll Nutr. 21: 339-43. PMID: 12166531
- alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. | Stapelberg, M., et al. 2004. Biochem Biophys Res Commun. 318: 636-41. PMID: 15144885
- Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects. | Neuzil, J., et al. 2004. Curr Cancer Drug Targets. 4: 355-72. PMID: 15180501
- Chemopreventive effect of dietary d-alpha-tocopheryl succinate supplementation on precancer colon aberrant crypt formation and vitamin E analogue levels in young and old rats. | Exon, JH., et al. 2004. Nutr Cancer. 49: 72-80. PMID: 15456638
- Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by alpha-tocopheryl succinate in human prostate cancer cells. | Zu, K., et al. 2005. Mol Cancer Ther. 4: 43-50. PMID: 15657352
- Plasma alpha-tocopherol profiles in sheep after oral administration of dl-alpha-tocopheryl acetate and d-alpha-tocopheryl succinate. | Hidiroglou, M. and Singh, K. 1991. J Dairy Sci. 74: 2718-23. PMID: 1918545
- Formulation of Docetaxel by folic acid-conjugated d-α-tocopheryl polyethylene glycol succinate 2000 (Vitamin E TPGS(2k)) micelles for targeted and synergistic chemotherapy. | Mi, Y., et al. 2011. Biomaterials. 32: 4058-66. PMID: 21396707
- Contrasting effects of α-tocopheryl succinate on cisplatin- and etoposide-induced apoptosis. | Kruspig, B., et al. 2013. Mitochondrion. 13: 533-8. PMID: 22971517
- Micelles of d-α-Tocopheryl Polyethylene Glycol 2000 Succinate (TPGS 2K) for Doxorubicin Delivery with Reversal of Multidrug Resistance. | Hao, T., et al. 2015. ACS Appl Mater Interfaces. 7: 18064-75. PMID: 26214761
- Tumor-specific penetrating peptides-functionalized hyaluronic acid-d-α-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers. | Liang, DS., et al. 2015. Biomaterials. 71: 11-23. PMID: 26310359
- Combination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy. | Cheng, Y., et al. 2022. J Zhejiang Univ Sci B. 23: 943-956. PMID: 36379613
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-α-Tocopheryl Succinate, 1 g | sc-200141 | 1 g | $42.00 | |||
D-α-Tocopheryl Succinate, 5 g | sc-200141A | 5 g | $49.00 | |||
D-α-Tocopheryl Succinate, 25 g | sc-200141B | 25 g | $112.00 | |||
D-α-Tocopheryl Succinate, 100 g | sc-200141C | 100 g | $333.00 | |||
D-α-Tocopheryl Succinate, 1 kg | sc-200141D | 1 kg | $3066.00 |