Date published: 2025-10-18

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Butylated hydroxyanisole (CAS 25013-16-5)

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Alternate Names:
2(3)-tert-Butyl-4-methoxyphenol; 2(3)-t-Butylhydroquinone monomethyl ether; BHA
Application:
Butylated hydroxyanisole is an industrial antioxidant
CAS Number:
25013-16-5
Molecular Weight:
180.24
Molecular Formula:
C11H16O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Butylated hydroxyanisole, also known as Butylhydroxyanisole (BHA), serves as a valuable antioxidant extensively employed in the food industry to combat food spoilage and oxidation. This synthetic phenolic compound consists of two isomers, namely 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. With a long-standing history of use, Butylated hydroxyanisole finds application in various food products, including fats, oils, and baked goods. Its inclusion in studies enables the determination of food product shelf life and the evaluation of antioxidant efficacy. Moreover, Butylated hydroxyanisole proves beneficial in examining the impact of food additives and preservatives on overall food quality. Acting as an antioxidant, Butylated hydroxyanisole operates by scavenging free radicals and impeding the oxidation process of fats and oils. By forming a protective layer on the surface of food products, it effectively hinders the oxidation of fats and oils. Additionally, Butylated hydroxyanisole inhibits the formation of detrimental compounds such as hydroperoxides, which have the potential to induce food spoilage.


Butylated hydroxyanisole (CAS 25013-16-5) References

  1. Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives.  |  Williams, GM., et al. 1999. Food Chem Toxicol. 37: 1027-38. PMID: 10541460
  2. Butylated hydroxyanisole inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis and GSH depletion.  |  Moon, HJ. and Park, WH. 2011. Mol Cell Biochem. 349: 179-86. PMID: 21113647
  3. Enhanced astaxanthin production from Haematococcus pluvialis using butylated hydroxyanisole.  |  Shang, M., et al. 2016. J Biotechnol. 236: 199-207. PMID: 27590093
  4. Butylated hydroxyanisole alters rat 5α-reductase and 3α-hydroxysteroid dehydrogenase: Implications for influences of neurosteroidogenesis.  |  Guo, J., et al. 2017. Neurosci Lett. 653: 132-138. PMID: 28552457
  5. Butylated hydroxyanisole encapsulated in gelatin fiber mats: Volatile release kinetics, functional effectiveness and application to strawberry preservation.  |  Li, L., et al. 2018. Food Chem. 269: 142-149. PMID: 30100416
  6. Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells.  |  Sun, Z., et al. 2019. J Hazard Mater. 379: 120794. PMID: 31238218
  7. Butylated hydroxyanisole induces testicular dysfunction in mouse testis cells by dysregulating calcium homeostasis and stimulating endoplasmic reticulum stress.  |  Ham, J., et al. 2020. Sci Total Environ. 702: 134775. PMID: 31710847
  8. Electrochemical sensor for determination of butylated hydroxyanisole (BHA) in food products using poly O-cresolphthalein complexone coated multiwalledcarbon nanotubes electrode.  |  Manoranjitham, JJ. and Narayanan, SS. 2021. Food Chem. 342: 128246. PMID: 33277123
  9. Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply?  |  Felter, SP., et al. 2021. Regul Toxicol Pharmacol. 121: 104887. PMID: 33556417
  10. A comparison of cell death mechanisms of antioxidants, butylated hydroxyanisole and butylated hydroxytoluene.  |  Mizobuchi, M., et al. 2022. Drug Chem Toxicol. 45: 1899-1906. PMID: 34013795
  11. Supplementing rabbit diets with butylated hydroxyanisole affects oxidative stress, growth performance, and meat quality.  |  Imbabi, T., et al. 2021. Animal. 15: 100339. PMID: 34425485
  12. The transformation mechanism and eco-toxicity evaluation of butylated hydroxyanisole in environment.  |  Wang, Y., et al. 2022. Ecotoxicol Environ Saf. 231: 113179. PMID: 35026586
  13. Molecularly imprinted electrochemical sensor based on 3D-flower-like MoS2 decorated with silver nanoparticles for highly selective detection of butylated hydroxyanisole.  |  Han, S., et al. 2022. Food Chem. 387: 132899. PMID: 35405559
  14. Molecular-substrate interaction on dynamic SERS detection of butylated hydroxyanisole on a silver nano-tripod substrate.  |  Liu, Z., et al. 2022. Phys Chem Chem Phys. 24: 26413-26420. PMID: 36300323
  15. Butylated hydroxyanisole mechanistic data and risk assessment: conditional species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion.  |  Whysner, J. and Williams, GM. 1996. Pharmacol Ther. 71: 137-51. PMID: 8910953

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Butylated hydroxyanisole, 5 g

sc-252527
5 g
$29.00

Butylated hydroxyanisole, 100 g

sc-252527A
100 g
$96.00