BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator. This protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PKR is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of ATF-3, p53, eIF2α and NF-κB. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.
Hu, W., et al., Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound. J. Pharmacol. Exp. Ther. 328, 866-872, (2009)
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