BEPP monohydrochloride A double-strand RNA-dependent protein kinase (PKR) activator

BEPP monohydrochloride (CAS 455311-98-5)

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Synonym: 1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride
Application: A double-strand RNA-dependent protein kinase (PKR) activator
CAS Number: 455311-98-5
Molecular Weight: 409.91
Molecular Formula: C23H23N3O2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator. This protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PKR is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of ATF-3, p53, eIF2α and NF-κB. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.


References

Hu, W., et al., Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound. J. Pharmacol. Exp. Ther. 328, 866-872, (2009)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO: >10 mg/mL
Storage :
Desiccate at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2858173
SMILES :
C1=CC=C(C=C1)CN2C3=CC=CC=C3N(C2=N)CC(COC4=CC=CC=C4)O.Cl

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Certificate of Analysis

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