BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator. This protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PKR is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of ATF-3, p53, eIF2α and NF-κB. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.
Hu, W., et al., Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound. J. Pharmacol. Exp. Ther. 328, 866-872, (2009)
Soluble in DMSO: >10 mg/mL
Desiccate at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.