Transaldolase Antibody (C-5): sc-365449
- Transaldolase Antibody (C-5) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 182-211 within an internal region of Transaldolase of human origin
- recommended for detection of Transaldolase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Transaldolase Antibody (C-5) for WB applications. These reagents are now offered in bundles with Transaldolase Antibody (C-5) (see ordering information below).
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Transaldolase Antibody (C-5) is a mouse monoclonal IgG1 antibody that detects Transaldolase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Transaldolase plays a crucial role in the nonoxidative phase of the pentose phosphate pathway, where Transaldolase is essential for the generation of NADPH and ribose-5-phosphate, both of which are vital for nucleic acid and lipid biosynthesis. Proper functioning of Transaldolase is particularly important in spermatozoa, as deficiencies in this enzyme can lead to male infertility due to compromised sperm structure and function. Furthermore, mutations in the gene encoding Transaldolase have been implicated in various health conditions, including multiple sclerosis, and are known to cause hepatosplenomegaly and skin telangiectases. Anti-Transaldolase antibody (C-5) enables researchers to gain insights into the enzyme′s role in metabolic pathways and implications in reproductive health and disease.
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Transaldolase Antibody (C-5) References:
- Pulmonary manifestations in a patient with transaldolase deficiency. | Jassim, N., et al. 2014. JIMD Rep. 12: 47-50. PMID: 23846909
- Clinical and molecular characteristics of two transaldolase-deficient patients. | Tylki-Szymanska, A., et al. 2014. Eur J Pediatr. 173: 1679-82. PMID: 24497183
- Arabinose 5-phosphate covalently inhibits transaldolase. | Light, SH. and Anderson, WF. 2014. J Struct Funct Genomics. 15: 41-4. PMID: 24510200
- Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans. | Bennett, CF., et al. 2017. PLoS Genet. 13: e1006695. PMID: 28355222
- An L-threonine transaldolase is required for L-threo-β-hydroxy-α-amino acid assembly during obafluorin biosynthesis. | Scott, TA., et al. 2017. Nat Commun. 8: 15935. PMID: 28649989
- Apparent Acetaminophen Toxicity in a Patient with Transaldolase Deficiency. | Lee-Barber, J., et al. 2019. JIMD Rep. 44: 9-15. PMID: 29923087
- Transaldolase haploinsufficiency in subjects with acetaminophen-induced liver failure. | Oaks, Z., et al. 2020. J Inherit Metab Dis. 43: 496-506. PMID: 31769880
- l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate. | Kumar, P., et al. 2021. ACS Chem Biol. 16: 86-95. PMID: 33337128
- Scalable and Selective β-Hydroxy-α-Amino Acid Synthesis Catalyzed by Promiscuous l-Threonine Transaldolase ObiH. | Doyon, TJ., et al. 2022. Chembiochem. 23: e202100577. PMID: 34699683
- Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism. | Snow, AJD., et al. 2023. Structure. 31: 244-252.e4. PMID: 36805128
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Transaldolase Antibody (C-5) | sc-365449 | 200 µg/ml | $322.00 | |||
Transaldolase Antibody (C-5): m-IgG Fc BP-HRP Bundle | sc-537805 | 200 µg Ab; 10 µg BP | $361.00 | |||
Transaldolase Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-535201 | 200 µg Ab; 40 µg BP | $361.00 | |||
Transaldolase Antibody (C-5): m-IgG1 BP-HRP Bundle | sc-545367 | 200 µg Ab; 20 µg BP | $361.00 | |||
Transaldolase (C-5) Neutralizing Peptide | sc-365449 P | 100 µg/0.5 ml | $69.00 |