Tafazzin Antibody (JK-2): sc-100870
- Tafazzin Antibody (JK-2) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Tafazzin of human origin
- recommended for detection of Tafazzin of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Tafazzin Antibody (JK-2). This work is in progress.
QUICK LINKS
SEE ALSO...
Tafazzin Antibody (JK-2) is a mouse monoclonal IgG2a antibody that detects Tafazzin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Tafazzin is a crucial single-pass membrane protein predominantly found in cardiac and skeletal muscle, where anti-Tafazzin antibody (JK-2) helps reveal its vital role in maintaining mitochondrial structure and function. Tafazzin exists in various isoforms, with those containing hydrophobic N-terminal domains being membrane-anchored, while shorter isoforms lacking this domain may be found in the cytoplasm. These isoforms influence localization and functional dynamics of Tafazzin within different cell types, including fibroblasts and leukocytes, which do not express membrane-bound forms. Mutations in the Tafazzin gene have been linked to several serious conditions, such as dilated cardiomyopathy, hypertrophic cardiomyopathy, endocardial fibroelastosis, left ventricular noncompaction, and Barth syndrome, a severe inherited disorder characterized by neutropenia, cardiac and skeletal myopathy, and short stature. Tafazzin (JK-2) antibody serves as an essential tool for researchers investigating this protein′s role in health and disease, providing insights into its function and dysregulation implications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Tafazzin Antibody (JK-2) References:
- The enigmatic role of tafazzin in cardiolipin metabolism. | Houtkooper, RH., et al. 2009. Biochim Biophys Acta. 1788: 2003-14. PMID: 19619503
- Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes. | He, Q. 2010. Am J Physiol Heart Circ Physiol. 299: H210-6. PMID: 20348225
- Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts. | He, Q., et al. 2013. Am J Physiol Heart Circ Physiol. 305: H1332-43. PMID: 23997105
- Cardiac mitochondrial structure and function in tafazzin-knockdown mice. | Kim, J., et al. 2018. Mitochondrion. 43: 53-62. PMID: 30389594
- TAZ encodes tafazzin, a transacylase essential for cardiolipin formation and central to the etiology of Barth syndrome. | Garlid, AO., et al. 2020. Gene. 726: 144148. PMID: 31647997
- The Function of Tafazzin, a Mitochondrial Phospholipid-Lysophospholipid Acyltransferase. | Schlame, M. and Xu, Y. 2020. J Mol Biol. 432: 5043-5051. PMID: 32234310
- Role of Tafazzin in Mitochondrial Function, Development and Disease. | Chin, MT. and Conway, SJ. 2020. J Dev Biol. 8: PMID: 32456129
- Tafazzin Modulates Allergen-Induced Mast Cell Inflammatory Mediator Secretion. | Maguire, ARR., et al. 2021. Immunohorizons. 5: 182-192. PMID: 33895725
- Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells. | Liang, Z., et al. 2024. Sci Rep. 14: 11497. PMID: 38769106
- Tafazzin regulates neutrophil maturation and inflammatory response. | Zakrzewski, P., et al. 2025. EMBO Rep. 26: 1590-1619. PMID: 39962231
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tafazzin Antibody (JK-2) | sc-100870 | 100 µg/ml | $339.00 |